Epigenetics & Nuclear Signaling Antibodies 3
Anti-FOXP1 Antibody (CAB5272)
(No reviews yet)
Write a Review
- SKU:
- CAB5272
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-FOXP1 Antibody |
| Antibody SKU: | CAB5272 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human FOXP1 (NP_001012523.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | K-562, A-549, Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human FOXP1 (NP_001012523.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMQE SGTE TKSN GSAI QNGS GGSN HLLE CGGL REGR SNGE TPAV DIGA ADLA HAQQ QQQQ WHLI NHQP SRSP SSWL KRLI SSPW ELEV LQVP LWGA VAET KMSG PVCQ PNPS PF |
| Gene ID: | 27086 |
| Uniprot: | Q9H334 |
| Cellular Location: | Nucleus |
| Calculated MW: | 12kDa/54kDa/65kDa/66kDa/74kDa/75kDa/77kDa |
| Observed MW: | 110kDa |
| Synonyms: | FOXP1, 12CC4, HSPC215, MFH, QRF1, hFKH1B |
| Background: | This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | FOXP1: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 3p13 Cellular Component: nucleoplasm; nucleus Molecular Function:androgen receptor binding; protein binding; protein self-association Biological Process: endothelial cell activation; macrophage activation; monocyte activation; negative regulation of B cell apoptosis; negative regulation of transcription, DNA-dependent; osteoclast differentiation; positive regulation of smooth muscle cell proliferation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of monocyte differentiation; regulation of tumor necrosis factor production; response to lipopolysaccharide; somatic stem cell maintenance Disease: Mental Retardation With Language Impairment And With Or Without Autistic Features |
| NCBI Summary: | This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H334 |
| NCBI GenInfo Identifier: | 14548062 |
| NCBI Gene ID: | 27086 |
| NCBI Accession: | Q9H334.1 |
| UniProt Secondary Accession: | Q9H334,Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9P0R1, A3QVP8 B3KV70, G5E9V8, |
| UniProt Related Accession: | Q9H334 |
| Molecular Weight: | 75kDa |
| NCBI Full Name: | Forkhead box protein P1 |
| NCBI Synonym Full Names: | forkhead box P1 |
| NCBI Official Symbol: | FOXP1 |
| NCBI Official Synonym Symbols: | MFH; QRF1; 12CC4; hFKH1B; HSPC215 |
| NCBI Protein Information: | forkhead box protein P1 |
| UniProt Protein Name: | Forkhead box protein P1 |
| UniProt Synonym Protein Names: | Mac-1-regulated forkhead |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXP1 |
 | Western blot analysis of extracts of various cell lines, using FOXP1 antibody (CAB5272) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 50s. |
 | Immunofluorescence analysis of U2OS cells using FOXP1 antibody (CAB5272). Blue: DAPI for nuclear staining. |
View AllClose
Related Products
FOXP1 Monoclonal Antibody
OverviewProduct Name:FOXP1 Monoclonal AntibodyProduct Code:CAB23442Reactivity:Human, Mouse, RatApplications:Western blotting, Imm
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक