Cell Cycle Antibodies 1
Anti-FOXO4 Antibody (CAB3307)
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- SKU:
- CAB3307
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-FOXO4 Antibody |
| Antibody SKU: | CAB3307 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 346-505 of human FOXO4 (NP_005929.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T, K-562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 346-505 of human FOXO4 (NP_005929.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FSPA EGPL SAGE GCFS SSQA LEAL LTSD TPPP PADV LMTQ VDPI LSQA PTLL LLGG LPSS SKLA TGVG LCPK PLEA PGPS SLVP TLSM IAPP PVMA SAPI PKAL GTPV LTPP TEAA SQDR MPQD LDLD MYME NLEC DMDN IISD LMDE GEGL DFNF EPDP |
| Gene ID: | 4303 |
| Uniprot: | P98177 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 47kDa/53kDa |
| Observed MW: | 63kDa |
| Synonyms: | AFX, AFX1, MLLT7, FOXO4 |
| Background: | This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | FOXO4: transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Oncoprotein; Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: Xq13.1 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:beta-catenin binding; DNA binding; enzyme binding; identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding Biological Process: cell cycle arrest; insulin receptor signaling pathway; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; stem cell differentiation; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P98177 |
| NCBI GenInfo Identifier: | 110825720 |
| NCBI Gene ID: | 4303 |
| NCBI Accession: | P98177.5 |
| UniProt Secondary Accession: | P98177,O43821, Q13720, Q3KPF1, Q8TDK9, B7WPJ7, |
| UniProt Related Accession: | P98177 |
| Molecular Weight: | 47,941 Da |
| NCBI Full Name: | Forkhead box protein O4 |
| NCBI Synonym Full Names: | forkhead box O4 |
| NCBI Official Symbol: | FOXO4 |
| NCBI Official Synonym Symbols: | AFX; AFX1; MLLT7 |
| NCBI Protein Information: | forkhead box protein O4 |
| UniProt Protein Name: | Forkhead box protein O4 |
| UniProt Synonym Protein Names: | Fork head domain transcription factor AFX1 |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXO4 |
| UniProt Entry Name: | FOXO4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FOXO4 antibody (CAB3307) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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