Cell Cycle Antibodies 1
Anti-FOXN3 Antibody (CAB15039)
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- SKU:
- CAB15039
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-FOXN3 Antibody |
| Antibody SKU: | CAB15039 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human FOXN3 (NP_005188.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human FOXN3 (NP_005188.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VRPL PITP IGVT AAMR NGIT SCRM RTES EPSC GSPV VSGD PKED HNYS SAKS SNAR STSP TSDS ISSS SSSA DDHY EFAT KGSQ EGSE GSEG SFRS HESP SDTE EDDR KHSQ KEPK DSLG DSGY ASQH KKRQ HFAK ARKV PSDT LPLK KRRT EKPP ESDD EEMK EAAG SLLH LAGI RSCL NNIT NRTA KGQK EQKE TTKN |
| Gene ID: | 1112 |
| Uniprot: | O00409 |
| Cellular Location: | Nucleus |
| Calculated MW: | 51kDa/53kDa |
| Observed MW: | 54kDa |
| Synonyms: | FOXN3, C14orf116, CHES1, PRO1635 |
| Background: | This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. |
| UniProt Protein Function: | FOXN3: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 14q31.3 Cellular Component: nucleus Molecular Function:protein binding; protein C-terminus binding Biological Process: mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00409 |
| NCBI GenInfo Identifier: | 8134361 |
| NCBI Gene ID: | 1112 |
| NCBI Accession: | O00409.1 |
| UniProt Secondary Accession: | O00409,Q96II7, Q9UIE7, |
| UniProt Related Accession: | O00409 |
| Molecular Weight: | 51,534 Da |
| NCBI Full Name: | Forkhead box protein N3 |
| NCBI Synonym Full Names: | forkhead box N3 |
| NCBI Official Symbol: | FOXN3 |
| NCBI Official Synonym Symbols: | CHES1; PRO1635; C14orf116 |
| NCBI Protein Information: | forkhead box protein N3 |
| UniProt Protein Name: | Forkhead box protein N3 |
| UniProt Synonym Protein Names: | Checkpoint suppressor 1 |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXN3 |
| UniProt Entry Name: | FOXN3_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using FOXN3 antibody (CAB15039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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