Cell Cycle Antibodies 1

Anti-FOXN3 Antibody (CAB15039)

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SKU:
CAB15039
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-FOXN3 Antibody
Antibody SKU:CAB15039
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human FOXN3 (NP_005188.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human FOXN3 (NP_005188.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VRPL PITP IGVT AAMR NGIT SCRM RTES EPSC GSPV VSGD PKED HNYS SAKS SNAR STSP TSDS ISSS SSSA DDHY EFAT KGSQ EGSE GSEG SFRS HESP SDTE EDDR KHSQ KEPK DSLG DSGY ASQH KKRQ HFAK ARKV PSDT LPLK KRRT EKPP ESDD EEMK EAAG SLLH LAGI RSCL NNIT NRTA KGQK EQKE TTKN
Gene ID:1112
Uniprot:O00409
Cellular Location:Nucleus
Calculated MW:51kDa/53kDa
Observed MW:54kDa
Synonyms:FOXN3, C14orf116, CHES1, PRO1635
Background:This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.
UniProt Protein Function:FOXN3: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 14q31.3

Cellular Component: nucleus

Molecular Function:protein binding; protein C-terminus binding

Biological Process: mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:O00409
NCBI GenInfo Identifier:8134361
NCBI Gene ID:1112
NCBI Accession:O00409.1
UniProt Secondary Accession:O00409,Q96II7, Q9UIE7,
UniProt Related Accession:O00409
Molecular Weight:51,534 Da
NCBI Full Name:Forkhead box protein N3
NCBI Synonym Full Names:forkhead box N3
NCBI Official Symbol:FOXN3  
NCBI Official Synonym Symbols:CHES1; PRO1635; C14orf116  
NCBI Protein Information:forkhead box protein N3
UniProt Protein Name:Forkhead box protein N3
UniProt Synonym Protein Names:Checkpoint suppressor 1
Protein Family:Forkhead box protein
UniProt Gene Name:FOXN3  
UniProt Entry Name:FOXN3_HUMAN
Anti-FOXN3 Antibody (CAB15039)Western blot analysis of extracts of mouse pancreas, using FOXN3 antibody (CAB15039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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