Epigenetics & Nuclear Signaling Antibodies 3

Anti-FOXK2 Antibody (CAB14245)

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SKU:
CAB14245
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-FOXK2 Antibody
Antibody SKU:CAB14245
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 511-660 of human FOXK2 (NP_004505.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse kidney, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 511-660 of human FOXK2 (NP_004505.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PKAE AQEN GDHR EVKV KVEP IPAI GHAT LGTA SRII QTAQ TTPV QTVT IVQQ APLG QHQL PIKT VTQN GTHV ASVP TAVH GQVN NAAA SPLH MLAT HASA SASL PTKR HNGD QPEQ PELK RIKT EDGE GIVI ALSV DTPP AAVR EKGV QN
Gene ID:3607
Uniprot:Q01167
Cellular Location:Nucleus
Calculated MW:34kDa/64kDa/69kDa
Observed MW:69kDa
Synonyms:FOXK2, ILF, ILF-1, ILF1
Background:The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.
UniProt Protein Function:Transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027).
NCBI Summary:The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
UniProt Code:Q01167
NCBI GenInfo Identifier:118572648
NCBI Gene ID:3607
NCBI Accession:Q01167.3
UniProt Secondary Accession:Q01167,Q13622, Q13623, Q13624, A6NEP5,
UniProt Related Accession:Q01167
Molecular Weight:34,325 Da
NCBI Full Name:Forkhead box protein K2
NCBI Synonym Full Names:forkhead box K2
NCBI Official Symbol:FOXK2  
NCBI Official Synonym Symbols:ILF; ILF1; ILF-1  
NCBI Protein Information:forkhead box protein K2
UniProt Protein Name:Forkhead box protein K2
UniProt Synonym Protein Names:Cellular transcription factor ILF-1; FOXK1; Interleukin enhancer-binding factor 1
Protein Family:Forkhead box protein
UniProt Gene Name:FOXK2  
UniProt Entry Name:FOXK2_HUMAN
Anti-FOXK2 Antibody (CAB14245)Western blot analysis of extracts of various cell lines, using FOXK2 antibody (CAB14245) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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