Epigenetics & Nuclear Signaling Antibodies 3
Anti-FOXI1 Antibody (CAB16852)
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- SKU:
- CAB16852
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-FOXI1 Antibody |
| Antibody SKU: | CAB16852 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOXI1 (NP_036320.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOXI1 (NP_036320.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSF DLPA PSPP RCSP QFPS IGQE PPEM NLYY ENFF HPQG VPSP QRPS FEGG GEYG ATPN PYLW FNGP TMTP PPYL PGPN ASPF LPQA YGVQ RPLL PSVS |
| Gene ID: | 2299 |
| Uniprot: | Q12951 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | FOXI1, FKH10, FKHL10, FREAC-6, FREAC6, HFH-3, HFH3 |
| Background: | This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4. |
| UniProt Protein Function: | FOXI1: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 5q34 Cellular Component: nucleus Molecular Function:sequence-specific DNA binding; transcription factor activity Biological Process: positive regulation of transcription from RNA polymerase II promoter Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome |
| NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12951 |
| NCBI GenInfo Identifier: | 150421552 |
| NCBI Gene ID: | 2299 |
| NCBI Accession: | Q12951.3 |
| UniProt Secondary Accession: | Q12951,Q14518, Q66SR7, Q8N6L8, |
| UniProt Related Accession: | Q12951 |
| Molecular Weight: | 30,814 Da |
| NCBI Full Name: | Forkhead box protein I1 |
| NCBI Synonym Full Names: | forkhead box I1 |
| NCBI Official Symbol: | FOXI1 |
| NCBI Official Synonym Symbols: | HFH3; FKH10; HFH-3; FKHL10; FREAC6; FREAC-6 |
| NCBI Protein Information: | forkhead box protein I1 |
| UniProt Protein Name: | Forkhead box protein I1 |
| UniProt Synonym Protein Names: | Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FREAC-6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH-3; HNF-3/fork-head homolog 3 |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXI1 |
| UniProt Entry Name: | FOXI1_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using FOXI1 antibody (CAB16852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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