Name: Anti-FOXI1 Antibody (CAB16852)
Brand: Epigenetics & Nuclear Signaling Antibodies 3
SKU: CAB16852
Availability: OutOfStock

Antibody Name:	Anti-FOXI1 Antibody
Antibody SKU:	CAB16852
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOXI1 (NP_036320.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOXI1 (NP_036320.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSSF DLPA PSPP RCSP QFPS IGQE PPEM NLYY ENFF HPQG VPSP QRPS FEGG GEYG ATPN PYLW FNGP TMTP PPYL PGPN ASPF LPQA YGVQ RPLL PSVS
Gene ID:	2299
Uniprot:	Q12951
Cellular Location:
Calculated MW:
Observed MW:	Refer to figures

Synonyms:

FOXI1, FKH10, FKHL10, FREAC-6, FREAC6, HFH-3, HFH3

Background:

This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4.

UniProt Protein Function:	FOXI1: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: 5q34 Cellular Component: nucleus Molecular Function:sequence-specific DNA binding; transcription factor activity Biological Process: positive regulation of transcription from RNA polymerase II promoter Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome
NCBI Summary:	This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q12951
NCBI GenInfo Identifier:	150421552
NCBI Gene ID:	2299
NCBI Accession:	Q12951.3
UniProt Secondary Accession:	Q12951,Q14518, Q66SR7, Q8N6L8,
UniProt Related Accession:	Q12951
Molecular Weight:	30,814 Da
NCBI Full Name:	Forkhead box protein I1
NCBI Synonym Full Names:	forkhead box I1
NCBI Official Symbol:	FOXI1
NCBI Official Synonym Symbols:	HFH3; FKH10; HFH-3; FKHL10; FREAC6; FREAC-6
NCBI Protein Information:	forkhead box protein I1
UniProt Protein Name:	Forkhead box protein I1
UniProt Synonym Protein Names:	Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FREAC-6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH-3; HNF-3/fork-head homolog 3
Protein Family:	Forkhead box protein
UniProt Gene Name:	FOXI1
UniProt Entry Name:	FOXI1_HUMAN

Western blot analysis of extracts of mouse kidney, using FOXI1 antibody (CAB16852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

Antibodies

FOXI1 Antibody (PACO03675)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)