Epigenetics & Nuclear Signaling Antibodies 3
Anti-FOXF1 Antibody (CAB17356)
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- SKU:
- CAB17356
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-FOXF1 Antibody |
| Antibody SKU: | CAB17356 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-379 of human FOXF1 (NP_001442.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-379 of human FOXF1 (NP_001442.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLGF NHLP DTYG FQGS AGGL SCPP NSLA LEGG LGMM NGHL PGNV DGMA LPSH SVPH LPSN GGHS YMGG CGGA AAGE YPHH DSSV PASP LLPT GAGG VMEP HAVY SGSA AAWP PSAS AALN SGAS YIKQ QPLS PCNP AANP LSGS LSTH SLEQ PYLH QNSH NAPA ELQG IPRY HSQS PSMC DRKE FVFS FNAM ASSS MHSA GGGS YYHQ QVTY QDIK PCVM |
| Gene ID: | 2294 |
| Uniprot: | Q12946 |
| Cellular Location: | Nucleus |
| Calculated MW: | 40kDa |
| Observed MW: | Refer to figures |
| Synonyms: | FOXF1, ACDMPV, FKHL5, FREAC1 |
| Background: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. |
| UniProt Protein Function: | FOXF1: Probable transcription activator for a number of lung- specific genes. Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn. |
| UniProt Protein Details: | Protein type:DNA-binding; Motility/polarity/chemotaxis; Transcription factor Chromosomal Location of Human Ortholog: 16q24 Cellular Component: nucleus; transcription factor complex Molecular Function:DNA binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding Biological Process: blood vessel development; embryonic digestive tract morphogenesis; embryonic ectodermal gut morphogenesis; gut development; heart development; in utero embryonic development; lung development; midgut development; morphogenesis of a branching structure; pancreas development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; respiratory tube development Disease: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins |
| NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12946 |
| NCBI GenInfo Identifier: | 238054293 |
| NCBI Gene ID: | 2294 |
| NCBI Accession: | Q12946.2 |
| UniProt Secondary Accession: | Q12946,Q5FWE5, B2RAF4, |
| UniProt Related Accession: | Q12946 |
| Molecular Weight: | 40,122 Da |
| NCBI Full Name: | Forkhead box protein F1 |
| NCBI Synonym Full Names: | forkhead box F1 |
| NCBI Official Symbol: | FOXF1 |
| NCBI Official Synonym Symbols: | FKHL5; ACDMPV; FREAC1 |
| NCBI Protein Information: | forkhead box protein F1 |
| UniProt Protein Name: | Forkhead box protein F1 |
| UniProt Synonym Protein Names: | Forkhead-related activator 1; FREAC-1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1 |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXF1 |
| UniProt Entry Name: | FOXF1_HUMAN |
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