Epigenetics & Nuclear Signaling Antibodies 1

Anti-FOXE1 Antibody (CAB12628)

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SKU:
CAB12628
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-FOXE1 Antibody
Antibody SKU:CAB12628
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 184-373 of human FOXE1 (NP_004464.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 184-373 of human FOXE1 (NP_004464.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AVPA ARPP YPGA VYAG YAPP SLAA PPPV YYPA ASPG PCRV FGLV PERP LSPE LGPA PSGP GGSC AFAS AGAP ATTT GYQP AGCT GARP ANPS AYAA AYAG PDGA YPQG AGSA IFAA AGRL AGPA SPPA GGSS GGVE TTVD FYGR TSPG QFGA LGAC YNPG GQLG GASA GAYH ARHA AAYP GGID RFVS AM
Gene ID:2304
Uniprot:O00358
Cellular Location:Nucleus
Calculated MW:38kDa
Observed MW:Refer to Figures
Synonyms:FOXE1, FKHL15, FOXE2, HFKH4, HFKL5, NMTC4, TITF2, TTF-2, TTF2
Background:This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4.
UniProt Protein Function:Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
NCBI Summary:This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016]
UniProt Code:O00358
NCBI GenInfo Identifier:21618325
NCBI Gene ID:2304
NCBI Accession:NP_004464.2
UniProt Secondary Accession:O00358,O75765, Q5T109, Q99526,
UniProt Related Accession:O00358
Molecular Weight:Observed: 34 kDaPredicted: 39 kDa
NCBI Full Name:forkhead box protein E1
NCBI Synonym Full Names:forkhead box E1
NCBI Official Symbol:FOXE1  
NCBI Official Synonym Symbols:TTF2; FOXE2; HFKH4; HFKL5; NMTC4; TITF2; TTF-2; FKHL15  
NCBI Protein Information:forkhead box protein E1
UniProt Protein Name:Forkhead box protein E1
UniProt Synonym Protein Names:Forkhead box protein E2; Forkhead-related protein FKHL15; HFKH4; HNF-3/fork head-like protein 5; HFKL5; Thyroid transcription factor 2; TTF-2
Protein Family:Transcription termination factor
UniProt Gene Name:FOXE1  
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