Epigenetics & Nuclear Signaling Antibodies 3

Anti-FOXD3 Antibody (CAB2926)

(No reviews yet) Write a Review
SKU:
CAB2926
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-FOXD3 Antibody
Antibody SKU:CAB2926
Antibody Size:50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human FOXD3
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa
Immunogen:A synthetic peptide of human FOXD3
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:27022
Uniprot:Q9UJU5
Cellular Location:Nucleus
Calculated MW:47kDa
Observed MW:48kDa
Synonyms:FOXD3, AIS1, Genesis, HFH2, VAMAS2
Background:This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1.
UniProt Protein Function:FOXD3: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: nucleoplasm; nuclear chromatin

Molecular Function:protein binding; double-stranded DNA binding; transcription factor activity

Biological Process: embryonic placenta development; transcription, DNA-dependent; somatic stem cell maintenance; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation

Disease: Autoimmune Disease, Susceptibility To, 1

NCBI Summary:This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]
UniProt Code:Q9UJU5
NCBI GenInfo Identifier:8134475
NCBI Gene ID:27022
NCBI Accession:Q9UJU5.1
UniProt Secondary Accession:Q9UJU5,Q9BYM2, Q9UDD1,
UniProt Related Accession:Q9UJU5
Molecular Weight:478
NCBI Full Name:Forkhead box protein D3
NCBI Synonym Full Names:forkhead box D3
NCBI Official Symbol:FOXD3  
NCBI Official Synonym Symbols:AIS1; HFH2; VAMAS2; Genesis  
NCBI Protein Information:forkhead box protein D3; HNF3/FH transcription factor genesis
UniProt Protein Name:Forkhead box protein D3
UniProt Synonym Protein Names:HNF3/FH transcription factor genesis
Protein Family:Forkhead box protein
UniProt Gene Name:FOXD3  
UniProt Entry Name:FOXD3_HUMAN
Anti-FOXD3 Antibody (CAB2926)Western blot analysis of extracts of HeLa cells, using FOXD3 antibody (CAB2926). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
View AllClose

0 Reviews

View AllClose

Related Products