Cell Biology Antibodies 5
Anti-FOSB Antibody (CAB14696)
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- SKU:
- CAB14696
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FOSB Antibody |
| Antibody SKU: | CAB14696 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOSB (NP_006723.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, SKOV3, HeLa, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOSB (NP_006723.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MFQA FPGD YDSG SRCS SSPS AESQ YLSS VDSF GSPP TAAA SQEC AGLG EMPG SFVP TVTA ITTS QDLQ WLVQ PTLI SSMA QSQG QPLA SQPP VVDP YDMP |
| Gene ID: | 2354 |
| Uniprot: | P53539 |
| Cellular Location: | Nucleus |
| Calculated MW: | 15kDa/20kDa/26kDa/27kDa/30kDa/31kDa/35kDa |
| Observed MW: | 37kDa |
| Synonyms: | FOSB, AP-1, G0S3, GOS3, GOSB |
| Background: | The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | FosB: FosB interacts with Jun proteins enhancing their DNA binding activity. Heterodimer. Belongs to the bZIP family. Fos subfamily. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: nucleus Molecular Function:DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; transcription factor binding Biological Process: transcription from RNA polymerase II promoter; response to drug; response to cAMP; response to mechanical stimulus; response to morphine; negative regulation of transcription from RNA polymerase II promoter; female pregnancy; response to progesterone stimulus; response to corticosterone stimulus; cellular response to hormone stimulus |
| NCBI Summary: | The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P53539 |
| NCBI GenInfo Identifier: | 1706888 |
| NCBI Gene ID: | 2354 |
| NCBI Accession: | P53539.1 |
| UniProt Secondary Accession: | P53539,A8K9K5, A8VJE1, A8VJE6, A8VJF0, A8VJF3, A8VJF7 A8VJG1, A8VJG5, A8VJG9, E7EPR6, E9PHJ3, |
| UniProt Related Accession: | P53539 |
| Molecular Weight: | 30,978 Da |
| NCBI Full Name: | Protein fosB |
| NCBI Synonym Full Names: | FBJ murine osteosarcoma viral oncogene homolog B |
| NCBI Official Symbol: | FOSB |
| NCBI Official Synonym Symbols: | AP-1; G0S3; GOS3; GOSB |
| NCBI Protein Information: | protein fosB; activator protein 1; G0/G1 switch regulatory protein 3 |
| UniProt Protein Name: | Protein fosB |
| UniProt Synonym Protein Names: | G0/G1 switch regulatory protein 3 |
| Protein Family: | Protein |
| UniProt Gene Name: | FOSB |
| UniProt Entry Name: | FOSB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FOSB antibody (CAB14696) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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