Cell Biology Antibodies 12
Anti-FNTA Antibody (CAB8805)
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- SKU:
- CAB8805
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FNTA Antibody |
| Antibody SKU: | CAB8805 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-379 of human FNTA (NP_002018.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HT-29, A-549, HL-60, Mouse heart, Mouse kidney, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-379 of human FNTA (NP_002018.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LKGI LQDR GLSK YPNL LNQL LDLQ PSHS SPYL IAFL VDIY EDML ENQC DNKE DILN KALE LCEI LAKE KDTI RKEY WRYI GRSL QSKH STEN DSPT NVQQ |
| Gene ID: | 2339 |
| Uniprot: | P49354 |
| Cellular Location: | |
| Calculated MW: | 36kDa/44kDa |
| Observed MW: | 44kDa |
| Synonyms: | FNTA, FPTA, PGGT1A, PTAR2, farnesyltransferase, CAAX box, alpha |
| Background: | Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. |
| UniProt Protein Function: | FNTA: Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK. Belongs to the protein prenyltransferase subunit alpha family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.5.1.58; EC 2.5.1.59 Chromosomal Location of Human Ortholog: 8p11 Cellular Component: cytoplasm; cytosol; microtubule associated complex Molecular Function:alpha-tubulin binding; CAAX-protein geranylgeranyltransferase activity; microtubule binding; protein binding; protein farnesyltransferase activity; protein geranylgeranyltransferase activity Biological Process: cell structure disassembly during apoptosis; protein farnesylation; protein geranylgeranylation; regulation of rhodopsin mediated signaling; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010] |
| UniProt Code: | P49354 |
| NCBI GenInfo Identifier: | 1346694 |
| NCBI Gene ID: | 2339 |
| NCBI Accession: | P49354.1 |
| UniProt Secondary Accession: | P49354,Q53XJ9, Q9UDC1, A6NJW0, |
| UniProt Related Accession: | P49354,AAB26814 |
| Molecular Weight: | 36,493 Da |
| NCBI Full Name: | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| NCBI Synonym Full Names: | farnesyltransferase, CAAX box, alpha |
| NCBI Official Symbol: | FNTA |
| NCBI Official Synonym Symbols: | FPTA; PTAR2; PGGT1A |
| NCBI Protein Information: | protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| UniProt Protein Name: | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| UniProt Synonym Protein Names: | CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha |
| Protein Family: | Protein farnesyltransferase/geranylgeranyltransferase |
| UniProt Gene Name: | FNTA |
| UniProt Entry Name: | FNTA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FNTA antibody (CAB8805) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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