Cell Biology Antibodies 6

Anti-FNIP1 Antibody (CAB15552)

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SKU:
CAB15552
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FNIP1 Antibody
Antibody SKU:CAB15552
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 270-350 of human FNIP1 (NP_588613.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 270-350 of human FNIP1 (NP_588613.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FPSP NSSL TRSC ASSY QRRW RRSQ TTSL ENGV FPRW SIEE SFNL SDES CGPN PGIV RKKK IAIG VIFS LSKD EDEN NKFN E
Gene ID:96459
Uniprot:Q8TF40
Cellular Location:Cytoplasm
Calculated MW:56kDa/127kDa/130kDa
Observed MW:Refer to figures
Synonyms:FNIP1
Background:This gene encodes a member of the folliculin-interacting protein family. The encoded protein binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK) and be involved in cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. A homologous binding partner of this protein, folliculin-interacting protein 2, has similar binding activities and may suggest functional redundancy within this protein family. Both folliculin-interacting proteins have also been shown to bind the molecular chaperone heat shock protein-90 (Hsp90) and they may function as a co-chaperones in the stabilization of tumor suppressor folliculin which is a target of Hsp90 chaperone activity.
UniProt Protein Function:FNIP1: May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. Belongs to the FNIP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytoplasm

Molecular Function:ATPase inhibitor activity; chaperone binding; guanyl-nucleotide exchange factor activity; protein binding

Biological Process: cellular response to starvation; immature B cell differentiation; negative regulation of caspase activity; negative regulation of TOR signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein complex assembly; regulation of protein amino acid phosphorylation; TOR signaling pathway

NCBI Summary:This gene encodes a member of the folliculin-interacting protein family. The encoded protein binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK) and be involved in cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. A homologous binding partner of this protein, folliculin-interacting protein 2, has similar binding activities and may suggest functional redundancy within this protein family. Both folliculin-interacting proteins have also been shown to bind the molecular chaperone heat shock protein-90 (Hsp90) and they may function as a co-chaperones in the stabilization of tumor suppressor folliculin which is a target of Hsp90 chaperone activity. [provided by RefSeq, Sep 2016]
UniProt Code:Q8TF40
NCBI GenInfo Identifier:1070257753
NCBI Gene ID:96459
NCBI Accession:NP_001333043.1
UniProt Secondary Accession:Q8TF40,Q86T47, Q9BUT0, D6RJH5,
UniProt Related Accession:Q8TF40
Molecular Weight:127,444 Da
NCBI Full Name:folliculin-interacting protein 1 isoform 4
NCBI Synonym Full Names:folliculin interacting protein 1
NCBI Official Symbol:FNIP1  
NCBI Protein Information:folliculin-interacting protein 1
UniProt Protein Name:Folliculin-interacting protein 1
Protein Family:Folliculin-interacting protein
UniProt Gene Name:FNIP1  
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