Cell Biology Antibodies 6
Anti-FNIP1 Antibody (CAB15552)
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- SKU:
- CAB15552
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FNIP1 Antibody |
| Antibody SKU: | CAB15552 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-350 of human FNIP1 (NP_588613.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-350 of human FNIP1 (NP_588613.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FPSP NSSL TRSC ASSY QRRW RRSQ TTSL ENGV FPRW SIEE SFNL SDES CGPN PGIV RKKK IAIG VIFS LSKD EDEN NKFN E |
| Gene ID: | 96459 |
| Uniprot: | Q8TF40 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 56kDa/127kDa/130kDa |
| Observed MW: | Refer to figures |
| Synonyms: | FNIP1 |
| Background: | This gene encodes a member of the folliculin-interacting protein family. The encoded protein binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK) and be involved in cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. A homologous binding partner of this protein, folliculin-interacting protein 2, has similar binding activities and may suggest functional redundancy within this protein family. Both folliculin-interacting proteins have also been shown to bind the molecular chaperone heat shock protein-90 (Hsp90) and they may function as a co-chaperones in the stabilization of tumor suppressor folliculin which is a target of Hsp90 chaperone activity. |
| UniProt Protein Function: | FNIP1: May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. Belongs to the FNIP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: cytoplasm Molecular Function:ATPase inhibitor activity; chaperone binding; guanyl-nucleotide exchange factor activity; protein binding Biological Process: cellular response to starvation; immature B cell differentiation; negative regulation of caspase activity; negative regulation of TOR signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein complex assembly; regulation of protein amino acid phosphorylation; TOR signaling pathway |
| NCBI Summary: | This gene encodes a member of the folliculin-interacting protein family. The encoded protein binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK) and be involved in cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. A homologous binding partner of this protein, folliculin-interacting protein 2, has similar binding activities and may suggest functional redundancy within this protein family. Both folliculin-interacting proteins have also been shown to bind the molecular chaperone heat shock protein-90 (Hsp90) and they may function as a co-chaperones in the stabilization of tumor suppressor folliculin which is a target of Hsp90 chaperone activity. [provided by RefSeq, Sep 2016] |
| UniProt Code: | Q8TF40 |
| NCBI GenInfo Identifier: | 1070257753 |
| NCBI Gene ID: | 96459 |
| NCBI Accession: | NP_001333043.1 |
| UniProt Secondary Accession: | Q8TF40,Q86T47, Q9BUT0, D6RJH5, |
| UniProt Related Accession: | Q8TF40 |
| Molecular Weight: | 127,444 Da |
| NCBI Full Name: | folliculin-interacting protein 1 isoform 4 |
| NCBI Synonym Full Names: | folliculin interacting protein 1 |
| NCBI Official Symbol: | FNIP1 |
| NCBI Protein Information: | folliculin-interacting protein 1 |
| UniProt Protein Name: | Folliculin-interacting protein 1 |
| Protein Family: | Folliculin-interacting protein |
| UniProt Gene Name: | FNIP1 |
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