| UniProt Protein Function: | FNDC5: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p35.1 Cellular Component: endoplasmic reticulum; extracellular region; plasma membrane Biological Process: response to muscle activity |
| NCBI Summary: | This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q8NAU1 |
| NCBI GenInfo Identifier: | 403314395 |
| NCBI Gene ID: | 252995 |
| NCBI Accession: | Q8NAU1.3 |
| UniProt Secondary Accession: | Q8NAU1,Q6P6D9, Q7Z676, A6NMC9, D3DPQ6, |
| UniProt Related Accession: | Q8NAU1 |
| Molecular Weight: | 23659 Da |
| NCBI Full Name: | Fibronectin type III domain-containing protein 5 |
| NCBI Synonym Full Names: | fibronectin type III domain containing 5 |
| NCBI Official Symbol: | FNDC5 |
| NCBI Official Synonym Symbols: | FRCP2; irisin |
| NCBI Protein Information: | fibronectin type III domain-containing protein 5 |
| UniProt Protein Name: | Fibronectin type III domain-containing protein 5 |
| UniProt Synonym Protein Names: | Fibronectin type III repeat-containing protein 2 |
| Protein Family: | Fibronectin type III domain-containing protein |
| UniProt Gene Name: | FNDC5 |
| UniProt Entry Name: | FNDC5_HUMAN |
