Cell Biology Antibodies 6

Anti-FN3KRP Antibody (CAB15512)

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SKU:
CAB15512
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FN3KRP Antibody
Antibody SKU:CAB15512
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human FN3KRP (NP_078895.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, U-251MG, MCF7, Mouse brain, Mouse kidney, Mouse lung, Mouse pancreas, Rat spleen, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human FN3KRP (NP_078895.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEEL LRRE LGCS SVRA TGHS GGGC ISQG RSYD TDQG RVFV KVNP KAEA RRMF EGEM ASLT AILK TNTV KVPK PIKV LDAP GGGS VLVM EHMD MRHL SSHA AKLG AQLA DLHL DNKK LGEM RLKE AGTV GRGG GQEE RPFV ARFG FDVV TCCG YLPQ VNDW QEDW VVFY ARQR IQPQ MDMV EKES GDRE ALQL WSAL QLKI PDLF RDLE IIPA LLHG DLWG GNVA EDSS GPVI FDPA SFYG HSEY ELAI AGMF GGFS SSFY SAYH GKIP KAPG FEKR LQLY QLFH YLNH WNHF GSGY RGSS LNIM RNLV K
Gene ID:79672
Uniprot:Q9HA64
Cellular Location:
Calculated MW:34kDa
Observed MW:35kDa
Synonyms:FN3KRP, FN3KL
Background:A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:FN3KRP: Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation. Belongs to the fructosamine kinase family.
UniProt Protein Details:

Protein type:EC 2.7.1.-; Kinase, other

Chromosomal Location of Human Ortholog: 17q25.3

Molecular Function:kinase activity

Biological Process: phosphorylation

NCBI Summary:A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
UniProt Code:Q9HA64
NCBI GenInfo Identifier:47606765
NCBI Gene ID:79672
NCBI Accession:Q9HA64.2
UniProt Secondary Accession:Q9HA64,Q969F4, Q9H0U7,
UniProt Related Accession:Q9HA64
Molecular Weight:309
NCBI Full Name:Ketosamine-3-kinase
NCBI Synonym Full Names:fructosamine 3 kinase related protein
NCBI Official Symbol:FN3KRP  
NCBI Official Synonym Symbols:FN3KL  
NCBI Protein Information:ketosamine-3-kinase; FN3K-RP; FN3K-related protein; fructosamine-3-kinase-related protein
UniProt Protein Name:Ketosamine-3-kinase
UniProt Synonym Protein Names:Fructosamine-3-kinase-related protein; FN3K-RP; FN3K-related protein
Protein Family:Ketosamine-3-kinase
UniProt Gene Name:FN3KRP  
UniProt Entry Name:KT3K_HUMAN
Anti-FN3KRP Antibody (CAB15512)Western blot analysis of extracts of various cell lines, using FN3KRP antibody (CAB15512) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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