Cell Biology Antibodies 4

Anti-FN3K Antibody (CAB13727)

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SKU:
CAB13727
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FN3K Antibody
Antibody SKU:CAB13727
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human FN3K (NP_071441.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, Mouse brain, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human FN3K (NP_071441.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEQL LRAE LRTA TLRA FGGP GAGC ISEG RAYD TDAG PVFV KVNR RTQA RQMF EGEV ASLE ALRS TGLV RVPR PMKV IDLP GGGA AFVM EHLK MKSL SSQA SKLG EQMA DLHL YNQK LREK LKEE ENTV GRRG EGAE PQYV DKFG FHTV TCCG FIPQ VNEW QDDW PTFF ARHR LQAQ LDLI EKDY ADRE AREL WSRL QVKI
Gene ID:64122
Uniprot:Q9H479
Cellular Location:
Calculated MW:35kDa
Observed MW:35kDa
Synonyms:FN3K
Background:A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation.
UniProt Protein Function:FN3K: May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme. Belongs to the fructosamine kinase family.
UniProt Protein Details:

Protein type:EC 2.7.1.-; Kinase, other

Chromosomal Location of Human Ortholog: 17q25.3

Molecular Function:fructosamine-3-kinase activity

Biological Process: fructoselysine metabolic process; epithelial cell differentiation; fructosamine metabolic process; phosphorylation

NCBI Summary:A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]
UniProt Code:Q9H479
NCBI GenInfo Identifier:11545906
NCBI Gene ID:64122
NCBI Accession:NP_071441.1
UniProt Related Accession:Q9H479
Molecular Weight:
NCBI Full Name:fructosamine-3-kinase
NCBI Synonym Full Names:fructosamine 3 kinase
NCBI Official Symbol:FN3K  
NCBI Protein Information:fructosamine-3-kinase
UniProt Protein Name:Fructosamine-3-kinase
Protein Family:Fructosamine-3-kinase
UniProt Gene Name:FN3K  
UniProt Entry Name:FN3K_HUMAN
Anti-FN3K Antibody (CAB13727)Western blot analysis of extracts of various cell lines, using FN3K antibody (CAB13727) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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