Cell Biology Antibodies 10
Anti-FMOD Antibody (CAB6375)
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- SKU:
- CAB6375
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FMOD Antibody |
| Antibody SKU: | CAB6375 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-376 of human FMOD (NP_002014.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, Mouse spleen, Rat spleen, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-376 of human FMOD (NP_002014.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QYED DPHW WFHY LRSQ QSTY YDPY DPYP YETY EPYP YGVD EGPA YTYG SPSP PDPR DCPQ ECDC PPNF PTAM YCDN RNLK YLPF VPSR MKYV YFQN NQIT SIQE GVFD NATG LLWI ALHG NQIT SDKV GRKV FSKL RHLE RLYL DHNN LTRM PGPL PRSL RELH LDHN QISR VPNN ALEG LENL TALY LQHN EIQE VGSS MRGL RSLI LLDL SYNH LRKV PDGL PSAL EQLY MEHN NVYT VPDS YFRG APKL LYVR LSHN SLTN NGLA SNTF NSSS LLEL DLSY NQLQ KIPP VNTN LENL YLQG NRIN EFSI SSFC TVVD VVNF SKLQ VLRL DGNE IKRS AMPA DAPL CLRL ASLI EI |
| Gene ID: | 2331 |
| Uniprot: | Q06828 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 43kDa |
| Observed MW: | 45kDa |
| Synonyms: | FMOD, FM, SLRR2E |
| Background: | Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | FMOD: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1q32 Cellular Component: extracellular matrix; extracellular region; extracellular space; Golgi lumen; lysosomal lumen Molecular Function:heparin binding; Roundabout binding Biological Process: axon extension involved in axon guidance; axonogenesis; keratan sulfate biosynthetic process; keratan sulfate catabolic process; regulation of axonogenesis; transforming growth factor beta receptor complex assembly |
| NCBI Summary: | Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q06828 |
| NCBI GenInfo Identifier: | 223590208 |
| NCBI Gene ID: | 2331 |
| NCBI Accession: | Q06828.2 |
| UniProt Secondary Accession: | Q06828,Q15331, Q8IV47, |
| UniProt Related Accession: | Q06828 |
| Molecular Weight: | 43,179 Da |
| NCBI Full Name: | Fibromodulin |
| NCBI Synonym Full Names: | fibromodulin |
| NCBI Official Symbol: | FMOD |
| NCBI Official Synonym Symbols: | FM; SLRR2E |
| NCBI Protein Information: | fibromodulin |
| UniProt Protein Name: | Fibromodulin |
| UniProt Synonym Protein Names: | Collagen-binding 59 kDa protein; Keratan sulfate proteoglycan fibromodulin; KSPG fibromodulin |
| Protein Family: | Fibromodulin |
| UniProt Gene Name: | FMOD |
| UniProt Entry Name: | FMOD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FMOD antibody (CAB6375) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat testis using FMOD antibody (CAB6375) at dilution of 1:100 (20x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using FMOD antibody (CAB6375) at dilution of 1:100 (20x lens). |
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