Immunology Antibodies 1

Anti-FMNL1 Antibody (CAB13010)

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SKU:
CAB13010
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-FMNL1 Antibody
Antibody SKU:CAB13010
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 900-1070 of human FMNL1 (NP_005883.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:LO2, A-549, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 900-1070 of human FMNL1 (NP_005883.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DLHF LDKA GSVS LDSV LADV RSLQ RGLE LTQR EFVR QDDC MVLK EFLR ANSP TMDK LLAD SKTA QEAF ESVV EYFG ENPK TTSP GLFF SLFS RFIK AYKK AEQE VEQW KKEA AAQE AGAD TPGK GEPP APKS PPKA RRPQ MDLI SELK RRQQ KEPL IYES DRDG AIED IIT
Gene ID:752
Uniprot:O95466
Cellular Location:Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Lipid-anchor, bleb, cell cortex, phagosome
Calculated MW:121kDa/122kDa/128kDa
Observed MW:150kDa
Synonyms:FMNL1, C17orf1, C17orf1B, FHOD4, FMNL, KW-13
Background:This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.
UniProt Protein Function:FMNL1: May play a role in the control of cell motility and survival of macrophages. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Belongs to the formin homology family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: membrane; plasma membrane; phagocytic vesicle; cell cortex; cytosol

Molecular Function:actin filament binding; protein binding; Rac GTPase binding; GTPase activating protein binding; profilin binding

Biological Process: substrate-bound cell migration; regulation of cell shape; actin filament severing; cortical actin cytoskeleton organization and biogenesis

UniProt Code:O95466
NCBI GenInfo Identifier:1519314519
NCBI Gene ID:
NCBI Accession:NP_005883
Molecular Weight:122kDa
NCBI Full Name:formin-like protein 1
UniProt Protein Name:Formin-like protein 1
UniProt Synonym Protein Names:CLL-associated antigen KW-13; Leukocyte formin
UniProt Gene Name:FMNL1  
UniProt Entry Name:FMNL_HUMAN
Anti-FMNL1 Antibody (CAB13010)Western blot analysis of extracts of various cell lines, using FMNL1 antibody (CAB13010) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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