Cell Biology Antibodies 15

Anti-FLG Antibody (CAB20011)

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SKU:
CAB20011
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FLG Antibody
Antibody SKU:CAB20011
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human FLG.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A375, A431, HepG2, TE-1, SGC7901, mouse stomach, mouse liver, rat liver
Immunogen:Recombinant protein of human FLG.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2312
Uniprot:P20930
Cellular Location:
Calculated MW:38-75kDa
Observed MW:30-100kDa
Anti-FLG Antibody (CAB20011)Western blot - FLG Rabbit pAb (CAB20011)
Synonyms:ATOD2
Background:The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
UniProt Protein Function:FLG: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Defects in FLG are the cause of ichthyosis vulgaris (VI); also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever. Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2). Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE- mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. Belongs to the S100-fused protein family.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: intermediate filament; intracellular membrane-bound organelle; nucleus

Molecular Function:calcium ion binding; protein binding; structural molecule activity

Biological Process: keratinocyte differentiation; multicellular organismal development

Disease: Dermatitis, Atopic, 2; Ichthyosis Vulgaris

NCBI Summary:The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
UniProt Code:P20930
NCBI GenInfo Identifier:84028206
NCBI Gene ID:2312
NCBI Accession:P20930.3
UniProt Secondary Accession:P20930,Q01720, Q5T583, Q9UC71,
UniProt Related Accession:P20930
Molecular Weight:
NCBI Full Name:Filaggrin
NCBI Synonym Full Names:filaggrin
NCBI Official Symbol:FLG  
NCBI Official Synonym Symbols:ATOD2  
NCBI Protein Information:filaggrin
UniProt Protein Name:Filaggrin
Protein Family:Filaggrin
UniProt Gene Name:FLG  
UniProt Entry Name:FILA_HUMAN
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