Anti-FLAP Antibody (CAB19632)

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SKU:
CAB19632

Description

Product Name:FLAP Rabbit mAb
Product Code:CAB19632
Size:20uL, 50uL, 100uL
Synonyms:FLAP
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human FLAP
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549, THP-1, U-937
Immunogen:A synthesized peptide derived from human FLAP
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:241
Uniprot:P20292
Calculated MW:16kDa
Observed MW:16KDa
UniProt Protein Function:ALOX5AP: Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. Belongs to the MAPEG family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Nuclear envelope; Membrane protein, multi-pass; Activator; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: endoplasmic reticulum; membrane; nuclear envelope; nuclear membrane

Molecular Function:arachidonic acid binding; glutathione peroxidase activity; glutathione transferase activity; leukotriene-C4 synthase activity; protein binding; protein N-terminus binding

Biological Process: leukotriene biosynthetic process; leukotriene metabolic process; lipoxygenase pathway

Disease: Stroke, Ischemic

NCBI Summary:This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
UniProt Code:P20292
NCBI GenInfo Identifier:120267
NCBI Gene ID:241
NCBI Accession:P20292.2
UniProt Secondary Accession:P20292,Q5VV04,
UniProt Related Accession:P20292
Molecular Weight:18,157 Da
NCBI Full Name:Arachidonate 5-lipoxygenase-activating protein
NCBI Synonym Full Names:arachidonate 5-lipoxygenase activating protein
NCBI Official Symbol:ALOX5AP  
NCBI Official Synonym Symbols:FLAP  
NCBI Protein Information:arachidonate 5-lipoxygenase-activating protein
UniProt Protein Name:Arachidonate 5-lipoxygenase-activating protein
UniProt Synonym Protein Names:FLAP; MK-886-binding protein
Protein Family:Arachidonate 5-lipoxygenase-activating protein
UniProt Gene Name:ALOX5AP  
UniProt Entry Name:AL5AP_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
FLAP
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