Cell Biology Antibodies 17

Anti-FKBP52 Antibody (CAB4356)

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SKU:
CAB4356
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FKBP52 Antibody
Antibody SKU:CAB4356
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human FKBP52
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Jurkat, Mouse testis, Mouse thymus, Rat testis
Immunogen:A synthesized peptide derived from human FKBP52
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2288
Uniprot:Q02790
Cellular Location:
Calculated MW:52kDa
Observed MW:56KDa
Synonyms:FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52
Background:The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
UniProt Protein Function:FKBP4: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
UniProt Protein Details:

Protein type:EC 5.2.1.8; Chaperone; Isomerase

Chromosomal Location of Human Ortholog: 12p13.33

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; nucleoplasm

Molecular Function:FK506 binding; heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein binding, bridging

Biological Process: negative regulation of microtubule polymerization or depolymerization; protein folding

NCBI Summary:The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
UniProt Code:Q02790
NCBI GenInfo Identifier:399866
NCBI Gene ID:2288
NCBI Accession:Q02790.3
UniProt Secondary Accession:Q02790,Q9UCP1, Q9UCV7, D3DUQ1,
UniProt Related Accession:Q02790
Molecular Weight:51,805 Da
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase FKBP4
NCBI Synonym Full Names:FK506 binding protein 4
NCBI Official Symbol:FKBP4  
NCBI Official Synonym Symbols:HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase  
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase FKBP4
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase FKBP4
UniProt Synonym Protein Names:51 kDa FK506-binding protein; FKBP51
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:FKBP4  
UniProt Entry Name:FKBP4_HUMAN
Anti-FKBP52 Antibody (CAB4356)Western blot - FKBP52 Rabbit mAb (CAB4356)
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