Anti-FKBP51/FKBP5 Antibody (CAB9090)
- SKU:
- CAB9090
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AIG6
- Synonyms:
- FKBP51
- Synonyms:
- FKBP54
- Synonyms:
- P54
- Synonyms:
- PPIase
- Synonyms:
- Ptg-10
Description
| Product Name: | FKBP51/FKBP5 Rabbit mAb |
| Product Code: | CAB9090 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human FKBP51/FKBP5 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse testis, Rat testis, HeLa, HT-1080, SH-SY5Y |
| Immunogen: | A synthesized peptide derived from human FKBP51/FKBP5 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2289 |
| Uniprot: | Q13451 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 51kDa |
| Observed MW: | 51kDa |
| UniProt Protein Function: | FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin. |
| UniProt Protein Details: | Protein type:EC 5.2.1.8; Isomerase; Chaperone Chromosomal Location of Human Ortholog: 6p21.31 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane Molecular Function:protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; heat shock protein binding Biological Process: protein peptidyl-prolyl isomerization; protein folding Disease: Major Depressive Disorder |
| NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] |
| UniProt Code: | Q13451 |
| NCBI GenInfo Identifier: | 2851536 |
| NCBI Gene ID: | 2289 |
| NCBI Accession: | Q13451.2 |
| UniProt Related Accession: | Q13451 |
| Molecular Weight: | 51kDa |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP5 |
| NCBI Synonym Full Names: | FKBP prolyl isomerase 5 |
| NCBI Official Symbol: | FKBP5 |
| NCBI Official Synonym Symbols: | P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP5 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP5 |
| UniProt Synonym Protein Names: | 51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase |
| Protein Family: | FK506-binding protein |
| UniProt Gene Name: | FKBP5 |
| UniProt Entry Name: | FKBP5_HUMAN |
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