Cell Death Antibodies 2
Anti-FKBP38 Antibody (CAB8701)
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- SKU:
- CAB8701
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-FKBP38 Antibody |
| Antibody SKU: | CAB8701 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human FKBP38 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Jurkat, Mouse brain, Mouse kidney, Rat brain |
| Immunogen: | A synthesized peptide derived from human FKBP38 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23770 |
| Uniprot: | Q14318 |
| Cellular Location: | |
| Calculated MW: | 52kDa |
| Observed MW: | 49KDa |
| Synonyms: | FKBP38, FKBPr38 |
| Background: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chaperone; Isomerase; Mitochondrial; EC 5.2.1.8; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p12 Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrial membrane; integral to endoplasmic reticulum membrane Molecular Function:identical protein binding; protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; metal ion binding Biological Process: smoothened signaling pathway; camera-type eye development; protein peptidyl-prolyl isomerization; viral reproduction; apoptosis; regulation of gene expression; multicellular organism growth; cell fate specification; positive regulation of BMP signaling pathway; dorsoventral neural tube patterning; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14318 |
| NCBI GenInfo Identifier: | 193806337 |
| NCBI Gene ID: | 23770 |
| NCBI Accession: | Q14318.2 |
| UniProt Related Accession: | Q14318 |
| Molecular Weight: | 55kDa |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP8 |
| NCBI Synonym Full Names: | FKBP prolyl isomerase 8 |
| NCBI Official Symbol: | FKBP8 |
| NCBI Official Synonym Symbols: | FKBP38; FKBPr38 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP8 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP8 |
| UniProt Synonym Protein Names: | 38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | FKBP8 |
| UniProt Entry Name: | FKBP8_HUMAN |
 | Western blot - FKBP38 Rabbit mAb (CAB8701) |
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