Cell Death Antibodies 2

Anti-FKBP38 Antibody (CAB8701)

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SKU:
CAB8701
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-FKBP38 Antibody
Antibody SKU:CAB8701
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human FKBP38
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Jurkat, Mouse brain, Mouse kidney, Rat brain
Immunogen:A synthesized peptide derived from human FKBP38
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23770
Uniprot:Q14318
Cellular Location:
Calculated MW:52kDa
Observed MW:49KDa
Synonyms:FKBP38, FKBPr38
Background:The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
UniProt Protein Function:FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Chaperone; Isomerase; Mitochondrial; EC 5.2.1.8; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrial membrane; integral to endoplasmic reticulum membrane

Molecular Function:identical protein binding; protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; metal ion binding

Biological Process: smoothened signaling pathway; camera-type eye development; protein peptidyl-prolyl isomerization; viral reproduction; apoptosis; regulation of gene expression; multicellular organism growth; cell fate specification; positive regulation of BMP signaling pathway; dorsoventral neural tube patterning; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
UniProt Code:Q14318
NCBI GenInfo Identifier:193806337
NCBI Gene ID:23770
NCBI Accession:Q14318.2
UniProt Related Accession:Q14318
Molecular Weight:55kDa
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase FKBP8
NCBI Synonym Full Names:FKBP prolyl isomerase 8
NCBI Official Symbol:FKBP8  
NCBI Official Synonym Symbols:FKBP38; FKBPr38  
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase FKBP8
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase FKBP8
UniProt Synonym Protein Names:38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:FKBP8  
UniProt Entry Name:FKBP8_HUMAN
Anti-FKBP38 Antibody (CAB8701)Western blot - FKBP38 Rabbit mAb (CAB8701)
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