Cell Biology Antibodies 11
Anti-FKBP2 Antibody (CAB8120)
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- SKU:
- CAB8120
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | FKBP2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8120 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-142 of human FKBP2 (NP_004461.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, SKOV3, Jurkat, HeLa, Mouse thymus, Mouse liver, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-142 of human FKBP2 (NP_004461.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ATGA EGKR KLQI GVKK RVDH CPIK SRKG DVLH MHYT GKLE DGTE FDSS LPQN QPFV FSLG TGQV IKGW DQGL LGMC EGEK RKLV IPSE LGYG ERGA PPKI PGGA TLVF EVEL LKIE RRTE L |
| Gene ID: | 2286 |
| Uniprot: | P26885 |
| Cellular Location: | Endoplasmic reticulum membrane, Peripheral membrane protein |
| Calculated MW: | 15kDa |
| Observed MW: | 14kDa |
| Synonyms: | FKBP2, FKBP-13, PPIase |
| Background: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
| UniProt Protein Function: | FKBP2: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP2 subfamily. |
| UniProt Protein Details: | Protein type:EC 5.2.1.8; Endoplasmic reticulum; Isomerase Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: endoplasmic reticulum Molecular Function:FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding |
| NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P26885 |
| NCBI GenInfo Identifier: | 23503054 |
| NCBI Gene ID: | 2286 |
| NCBI Accession: | P26885.2 |
| UniProt Secondary Accession: | P26885,Q5BJH9, Q9BTS7, |
| UniProt Related Accession: | P26885 |
| Molecular Weight: | 16kDa |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP2 |
| NCBI Synonym Full Names: | FK506 binding protein 2 |
| NCBI Official Symbol: | FKBP2 |
| NCBI Official Synonym Symbols: | PPIase; FKBP-13 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP2 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP2 |
| UniProt Synonym Protein Names: | 13 kDa FK506-binding protein; 13 kDa FKBP; FKBP-13; FK506-binding protein 2; FKBP-2; Immunophilin FKBP13; Rotamase |
| Protein Family: | FK506-binding protein |
| UniProt Gene Name: | FKBP2 |
 | Western blot analysis of extracts of various cell lines, using FKBP2 antibody (CAB8120) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using FKBP2 antibody (CAB8120) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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