Antibody Name:	Anti-FKBP1B Antibody
Antibody SKU:	CAB16375
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-80 of human FKBP1B (NP_473374.1).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	22Rv1, Mouse brain, Rat brain

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-80 of human FKBP1B (NP_473374.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MGVE IETI SPGD GRTF PKKG QTCV VHYT GMLQ NGKK FDSS RDRN KPFK FRIG KQEV IKGF EEGA AQLG PLSP LPIC PHPC
Gene ID:	2281
Uniprot:	P68106
Cellular Location:	Cytoplasm, Sarcoplasmic reticulum
Calculated MW:	8kDa/11kDa
Observed MW:	13kDa

Synonyms:

FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase

Background:

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.

UniProt Protein Function:	FKBP1B: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Isomerase; EC 5.2.1.8 Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: cytoplasm; cytosol; membrane; sarcoplasmic reticulum membrane; Z disc Molecular Function:calcium channel inhibitor activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; receptor binding; ryanodine-sensitive calcium-release channel activity Biological Process: 'de novo' protein folding; cytosolic calcium ion homeostasis; negative regulation of heart rate; negative regulation of protein phosphatase type 2B activity; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of sequestering of calcium ion; protein maturation via protein folding; protein peptidyl-prolyl isomerization; protein refolding; response to redox state
NCBI Summary:	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:	P68106
NCBI GenInfo Identifier:	61224185
NCBI Gene ID:	2281
NCBI Accession:	P68106.2
UniProt Secondary Accession:	P68106,Q13664, Q16645, Q53TM2, Q9BQ40,
UniProt Related Accession:	P68106
Molecular Weight:	8,802 Da
NCBI Full Name:	Peptidyl-prolyl cis-trans isomerase FKBP1B
NCBI Synonym Full Names:	FK506 binding protein 1B
NCBI Official Symbol:	FKBP1B
NCBI Official Synonym Symbols:	OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6
NCBI Protein Information:	peptidyl-prolyl cis-trans isomerase FKBP1B
UniProt Protein Name:	Peptidyl-prolyl cis-trans isomerase FKBP1B
UniProt Synonym Protein Names:	12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase; h-FKBP-12
Protein Family:	Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:	FKBP1B
UniProt Entry Name:	FKB1B_HUMAN

	Western blot analysis of extracts of various cell lines, using FKBP1B antibody (CAB16375) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
	Immunohistochemistry of paraffin-embedded rat heart using FKBP1B antibody (CAB16375) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse spinal cord using FKBP1B antibody (CAB16375) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse heart using FKBP1B antibody (CAB16375) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of L929 cells using FKBP1B Polyclonal Antibody (CAB16375) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.