KO Validated Antibodies 2

Anti-FKBP10 Antibody (CAB19870)[KO Validated]

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SKU:
CAB19870
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FKBP10 Antibody [KO Validated]
Antibody SKU:CAB19870
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human FKBP10.
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:293T
Immunogen:Recombinant protein of human FKBP10.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:60681
Uniprot:Q96AY3
Cellular Location:Endoplasmic reticulum lumen
Calculated MW:38kDa/64kDa
Observed MW:75KDa
Anti-FKBP10 Antibody [KO Validated] (CAB19870)Western blot analysis of extracts from normal (control) and FKBP10 knockout (KO) 293T cells, using FKBP10 antibody (CAB19870) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1S.
Synonyms:FKBP10, BRKS1, FKBP65, OI11, OI6, PPIASE, hFKBP65
Background:The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.
UniProt Protein Function:FKBP10: PPIases accelerate the folding of proteins during protein synthesis. Defects in FKBP10 are the cause of osteogenesis imperfecta type 6 (OI6). OI6 is a moderate to severe, autosomal recessive form of osteogenesis imperfecta characterized by increased serum alkaline phosphatase levels and bone histology exhibiting a fish scale-like lamellar pattern. Osteogenesis imperfecta defines a group of connective tissue disorders characterized by bone fragility and low bone mass.
UniProt Protein Details:

Protein type:Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: endoplasmic reticulum membrane

Molecular Function:FK506 binding; peptidyl-prolyl cis-trans isomerase activity

Disease: Bruck Syndrome 1; Osteogenesis Imperfecta, Type Xi

NCBI Summary:The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
UniProt Code:Q96AY3
NCBI GenInfo Identifier:23396594
NCBI Gene ID:60681
NCBI Accession:Q96AY3.1
UniProt Secondary Accession:Q96AY3,Q7Z3R4, Q9H3N3, Q9H6J3, Q9H6N5, Q9UF89,
UniProt Related Accession:Q96AY3
Molecular Weight:38,950 Da
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase FKBP10
NCBI Synonym Full Names:FK506 binding protein 10
NCBI Official Symbol:FKBP10  
NCBI Official Synonym Symbols:OI6; OI11; BRKS1; FKBP65; PPIASE; hFKBP65  
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase FKBP10
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase FKBP10
UniProt Synonym Protein Names:65 kDa FK506-binding protein; 65 kDa FKBP; FKBP-65; FK506-binding protein 10; FKBP-10; Immunophilin FKBP65; Rotamase
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:FKBP10  
UniProt Entry Name:FKB10_HUMAN
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