Cardiovascular Antibodies
Anti-FIGF Antibody (CAB13617)
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- SKU:
- CAB13617
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-FIGF Antibody |
| Antibody SKU: | CAB13617 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human FIGF (NP_004460.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human FIGF (NP_004460.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QGSS NEHG PVKR SSQS TLER SEQQ IRAA SSLE ELLR ITHS EDWK LWRC RLRL KSFT SMDS RSAS HRST RFAA TFYD IETL KVID EEWQ RTQC SPRE TCVE VASE LGKS TNTF FKPP CVNV FRCG GCCN EESL ICMN TSTS YISK QLFE ISVP LTSV PELV PVKV ANHT GCKC LPTA PRHP YSII RRSI QIPE EDRC SHSK K |
| Gene ID: | 2277 |
| Uniprot: | O43915 |
| Cellular Location: | Secreted |
| Calculated MW: | 40kDa |
| Observed MW: | 54kDa |
| Synonyms: | VEGFD, FIGF, VEGF-D |
| Background: | The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. |
| UniProt Protein Function: | VEGFD: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Belongs to the PDGF/VEGF growth factor family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Cytokine; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xp22.31 Cellular Component: extracellular region Molecular Function:chemoattractant activity; platelet-derived growth factor receptor binding; vascular endothelial growth factor receptor binding Biological Process: induction of positive chemotaxis; platelet degranulation; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011] |
| UniProt Code: | O43915 |
| NCBI GenInfo Identifier: | 17367984 |
| NCBI Gene ID: | 2277 |
| NCBI Accession: | O43915.1 |
| UniProt Secondary Accession: | O43915,B2R7Z3, |
| UniProt Related Accession: | O43915 |
| Molecular Weight: | 40,444 Da |
| NCBI Full Name: | Vascular endothelial growth factor D |
| NCBI Synonym Full Names: | c-fos induced growth factor |
| NCBI Official Symbol: | FIGF |
| NCBI Official Synonym Symbols: | VEGFD; VEGF-D |
| NCBI Protein Information: | vascular endothelial growth factor D |
| UniProt Protein Name: | Vascular endothelial growth factor D |
| UniProt Synonym Protein Names: | c-Fos-induced growth factor; FIGF |
| UniProt Gene Name: | FIGF |
| UniProt Entry Name: | VEGFD_HUMAN |
 | Western blot analysis of extracts of 293T cells, using VEGFD antibody (CAB13617) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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