Signal Transduction Antibodies 1

Anti-FICD Antibody (CAB13757)

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SKU:
CAB13757
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-FICD Antibody
Antibody SKU:CAB13757
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 119-458 of human FICD (NP_009007.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, A-549, Jurkat, HeLa, Mouse lung, Rat ovary
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 119-458 of human FICD (NP_009007.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QGKR EKAQ KLFM HALK MDPD FVDA LTEF GIFS EEDK DIIQ ADYL YTRA LTIS PYHE KALV NRDR TLPL VEEI DQRY FSII DSKV KKVM SIPK GNSA LRRV MEET YYHH IYHT VAIE GNTL TLSE IRHI LETR YAVP GKSL EEQN EVIG MHAA MKYI NTTL VSRI GSVT ISDV LEIH RRVL GYVD PVEA GRFR TTQV LVGH HIPP HPQD VEKQ MQEF VQWL NSEE AMNL HPVE FAAL AHYK LVYI HPFI DGNG RTSR LLMN LILM QAGY PPIT IRKE QRSD YYHV LEAA NEGD VRPF IRFI AKCT ETTL DTLL FATT EYSV ALPE AQPN HSGF KETL PVKP
Gene ID:11153
Uniprot:Q9BVA6
Cellular Location:Membrane, Single-pass membrane protein
Calculated MW:51kDa
Observed MW:51kDa
Synonyms:FICD, HIP13, HYPE, UNQ3041
Background:
UniProt Protein Function:FICD: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified. Belongs to the fic family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Adenylyltransferase; EC 2.7.7.n1

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: integral to membrane

Molecular Function:ATP binding

Biological Process: protein amino acid adenylylation

UniProt Code:Q9BVA6
NCBI GenInfo Identifier:74761284
NCBI Gene ID:11153
NCBI Accession:Q9BVA6.2
UniProt Secondary Accession:Q9BVA6,O75406,
UniProt Related Accession:Q9BVA6
Molecular Weight:51,778 Da
NCBI Full Name:Adenosine monophosphate-protein transferase FICD
NCBI Synonym Full Names:FIC domain containing
NCBI Official Symbol:FICD  
NCBI Official Synonym Symbols:HYPE; HIP13; UNQ3041  
NCBI Protein Information:adenosine monophosphate-protein transferase FICD; HIP-13; AMPylator FICD; huntingtin yeast partner E; FIC domain-containing protein; huntingtin interactor protein E; Huntingtin interacting protein E; huntingtin-interacting protein E; huntingtin interacting protein 13; huntingtin-interacting protein 13; fic S-phase protein cell division homolog
UniProt Protein Name:Adenosine monophosphate-protein transferase FICD
UniProt Synonym Protein Names:AMPylator FICD; FIC domain-containing protein; Huntingtin yeast partner E; Huntingtin-interacting protein 13; HIP-13; Huntingtin-interacting protein E
Protein Family:Adenosine monophosphate-protein transferase
UniProt Gene Name:FICD  
UniProt Entry Name:FICD_HUMAN
Anti-FICD Antibody (CAB13757)Western blot analysis of extracts of various cell lines, using FICD antibody (CAB13757) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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