Anti-FHL2 Antibody (CAB3670)

(No reviews yet) Write a Review
SKU:
CAB3670
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
AAG11
Synonyms:
DRAL
Synonyms:
FHL-2
Synonyms:
SLIM-3
Synonyms:
SLIM3
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:FHL2 Rabbit mAb
Product Code:CAB3670
Size:20uL, 50uL, 100uL
Synonyms:AAG11, DRAL, FHL-2, SLIM-3, SLIM3
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human FHL2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse heart, Rat heart, SKOV3, RD
Immunogen:A synthesized peptide derived from human FHL2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2274
Uniprot:Q14192
Calculated MW:32kDa
Observed MW:32kDa
UniProt Protein Function:FHL2: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2q12.2

Cellular Component: nucleoplasm; focal adhesion; M band; nucleus; Z disc; actin cytoskeleton

Molecular Function:identical protein binding; protein binding; androgen receptor binding; zinc ion binding; transcription coactivator activity; transcription factor binding

Biological Process: osteoblast differentiation; atrial cardiac muscle cell development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; ventricular cardiac muscle cell development; androgen receptor signaling pathway; response to hormone stimulus; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
UniProt Code:Q14192
NCBI GenInfo Identifier:116241364
NCBI Gene ID:2274
NCBI Accession:Q14192.3
UniProt Related Accession:Q14192
Molecular Weight:~ 32kDa
NCBI Full Name:Four and a half LIM domains protein 2
NCBI Synonym Full Names:four and a half LIM domains 2
NCBI Official Symbol:FHL2  
NCBI Official Synonym Symbols:DRAL; AAG11; FHL-2; SLIM3; SLIM-3  
NCBI Protein Information:four and a half LIM domains protein 2
UniProt Protein Name:Four and a half LIM domains protein 2
UniProt Synonym Protein Names:LIM domain protein DRAL; Skeletal muscle LIM-protein 3; SLIM-3
Protein Family:Four and a half LIM domains protein
UniProt Gene Name:FHL2  
UniProt Entry Name:FHL2_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products