Cell Biology Antibodies 5

Anti-FGGY Antibody (CAB14904)

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SKU:
CAB14904
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FGGY Antibody
Antibody SKU:CAB14904
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human FGGY (NP_060761.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HepG2, A-431, Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human FGGY (NP_060761.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSGG EQKP ERYY VGVD VGTG SVRA ALVD QSGV LLAF ADQP IKNW EPQF NHHE QSSE DIWA ACCV VTKK VVQG IDLN QIRG LGFD ATCS LVVL DKQF HPLP VNQE GDSH RNVI MWLD HRAV SQVN RINE TKHS VLQY VGGV MSVE MQAP KLLW LKEN LREI CWDK AGHF FDLP DFLS WKAT GVTA RSLC SLVC KWTY SAEK GWDD SFWK MIGL EDFV ADNY SKIG NQVL PPGA SLGN GLTP EAAR DLGL LP
Gene ID:55277
Uniprot:Q96C11
Cellular Location:
Calculated MW:26kDa/27kDa/47kDa/50kDa/59kDa/62kDa
Observed MW:70kDa
Synonyms:FGGY
Background:This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:FGGY: Defects in FGGY are associated with sporadic amyotrophic lateral sclerosis (ALS). Amyotrophic lateral sclerosis is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. Belongs to the FGGY kinase family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Kinase, other; EC 2.7.1.-

Chromosomal Location of Human Ortholog: 1p32.1

Molecular Function:kinase activity; phosphotransferase activity, alcohol group as acceptor

Biological Process: carbohydrate metabolic process; phosphorylation

UniProt Code:Q96C11
NCBI GenInfo Identifier:164663828
NCBI Gene ID:
NCBI Accession:NP_060761
Molecular Weight:
NCBI Full Name:FGGY carbohydrate kinase domain-containing protein isoform b
UniProt Protein Name:FGGY carbohydrate kinase domain-containing protein
Protein Family:FGGY carbohydrate kinase domain-containing protein
UniProt Gene Name:FGGY  
UniProt Entry Name:FGGY_HUMAN
Anti-FGGY Antibody (CAB14904)Western blot analysis of extracts of various cell lines, using FGGY antibody (CAB14904) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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