Name: Anti-FGFBP1 Antibody (CAB7458)
Brand: Cell Biology Antibodies 11
SKU: CAB7458
Availability: OutOfStock

Antibody Name:	Anti-FGFBP1 Antibody
Antibody SKU:	CAB7458
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-234 of human FGFBP1 (NP_005121.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	A-549, HepG2, NIH/3T3, Mouse kidney, Mouse lung, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-234 of human FGFBP1 (NP_005121.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	KKKV KNGL HSKV VSEQ KDTL GNTQ IKQK SRPG NKGK FVTK DQAN CRWA ATEQ EEGI SLKV ECTQ LDHE FSCV FAGN PTSC LKLK DERV YWKQ VARN LRSQ KDIC RYSK TAVK TRVC RKDF PESS LKLV SSTL FGNT KPRK EKTE MSPR EHIK GKET TPSS LAVT QTMA TKAP ECVE DPDM ANQR KTAL EFCG ETWS SLCT FFLS IVQD TSC
Gene ID:	9982
Uniprot:	Q14512
Cellular Location:	Cell membrane, Peripheral membrane protein, Secreted, extracellular space
Calculated MW:	26kDa
Observed MW:	30kDa

Synonyms:

FGFBP1, FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17

Background:

This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.

UniProt Protein Function:	FGFBP1: Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. Belongs to the fibroblast growth factor-binding protein family.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 4p15.32 Cellular Component: extracellular space; cell surface; plasma membrane Molecular Function:heparin binding; protein binding; fibroblast growth factor binding Biological Process: negative regulation of cell proliferation; cell-cell signaling; positive regulation of cell proliferation; positive regulation of fibroblast growth factor receptor signaling pathway; signal transduction
NCBI Summary:	This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
UniProt Code:	Q14512
NCBI GenInfo Identifier:	74739840
NCBI Gene ID:	9982
NCBI Accession:	Q14512.1
UniProt Secondary Accession:	Q14512,A8K5J2,
UniProt Related Accession:	Q14512
Molecular Weight:	234
NCBI Full Name:	Fibroblast growth factor-binding protein 1
NCBI Synonym Full Names:	fibroblast growth factor binding protein 1
NCBI Official Symbol:	FGFBP1
NCBI Official Synonym Symbols:	FGFBP; HBP17; FGF-BP; FGF-BP1; FGFBP-1
NCBI Protein Information:	fibroblast growth factor-binding protein 1; FGF-binding protein 1; 17 kDa HBGF-binding protein; heparin-binding growth factor binding protein; 17 kDa heparin-binding growth factor-binding protein
UniProt Protein Name:	Fibroblast growth factor-binding protein 1
UniProt Synonym Protein Names:	17 kDa heparin-binding growth factor-binding protein; 17 kDa HBGF-binding protein; HBp17
Protein Family:	Fibroblast growth factor-binding protein
UniProt Gene Name:	FGFBP1
UniProt Entry Name:	FGFP1_HUMAN

Western blot analysis of extracts of various cell lines, using FGFBP1 antibody (CAB7458) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

ELISA Kits

Human FGFBP1 ELISA Kit

Human FGFBP1 (Fibroblast Growth Factor Binding Protein 1) ELISA Kit (HUES02209)

Human Fibroblast growth factor-binding protein 1 (FGFBP1) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)