Cell Biology Antibodies 1
Anti-FGF21 Antibody (CAB10368)
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- SKU:
- CAB10368
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FGF21 Antibody |
| Antibody SKU: | CAB10368 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-209 of human FGF21 (NP_061986.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-209 of human FGF21 (NP_061986.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HPIP DSSP LLQF GGQV RQRY LYTD DAQQ TEAH LEIR EDGT VGGA ADQS PESL LQLK ALKP GVIQ ILGV KTSR FLCQ RPDG ALYG SLHF DPEA CSFR ELLL EDGY NVYQ SEAH GLPL HLPG NKSP HRDP APRG PARF LPLP GLPP ALPE PPGI LAPQ PPDV GSSD PLSM VGPS QGRS PSYA S |
| Gene ID: | 26291 |
| Uniprot: | Q9NSA1 |
| Cellular Location: | Secreted |
| Calculated MW: | 22kDa |
| Observed MW: | 16kDa |
| Synonyms: | FGF21 |
| Background: | Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. |
| UniProt Protein Function: | FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular region Molecular Function:protein binding; growth factor activity; fibroblast growth factor receptor binding Biological Process: positive regulation of glucose import; cell-cell signaling; positive regulation of cell proliferation; positive regulation of low-density lipoprotein receptor biosynthetic process; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NSA1 |
| NCBI GenInfo Identifier: | 13626703 |
| NCBI Gene ID: | 26291 |
| NCBI Accession: | Q9NSA1.1 |
| UniProt Secondary Accession: | Q9NSA1,Q8N683, |
| UniProt Related Accession: | Q9NSA1 |
| Molecular Weight: | 22,300 Da |
| NCBI Full Name: | Fibroblast growth factor 21 |
| NCBI Synonym Full Names: | fibroblast growth factor 21 |
| NCBI Official Symbol: | FGF21 |
| NCBI Protein Information: | fibroblast growth factor 21 |
| UniProt Protein Name: | Fibroblast growth factor 21 |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF21 |
| UniProt Entry Name: | FGF21_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FGF21 antibody (CAB10368) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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