Cell Biology Antibodies 10
Anti-FGF19 Antibody (CAB6589)
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- SKU:
- CAB6589
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FGF19 Antibody |
| Antibody SKU: | CAB6589 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-216 of human FGF19 (NP_005108.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SW620 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-216 of human FGF19 (NP_005108.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LAFS DAGP HVHY GWGD PIRL RHLY TSGP HGLS SCFL RIRA DGVV DCAR GQSA HSLL EIKA VALR TVAI KGVH SVRY LCMG ADGK MQGL LQYS EEDC AFEE EIRP DGYN VYRS EKHR LPVS LSSA KQRQ LYKN RGFL PLSH FLPM LPMV PEEP EDLR GHLE SDMF SSPL ETDS MDPF GLVT GLEA VRSP SFEK |
| Gene ID: | 9965 |
| Uniprot: | O95750 |
| Cellular Location: | Secreted |
| Calculated MW: | 24kDa |
| Observed MW: | 24kDa |
| Synonyms: | FGF19 |
| Background: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. |
| UniProt Protein Function: | FGF19: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Belongs to the heparin-binding growth factors family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide; Secreted; Cell development/differentiation Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: extracellular region Molecular Function:protein binding; growth factor activity; fibroblast growth factor receptor binding Biological Process: epidermal growth factor receptor signaling pathway; nervous system development; positive regulation of glucose import; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; heart development; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; positive regulation of JNK cascade; positive regulation of protein amino acid phosphorylation; neural crest cell migration |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95750 |
| NCBI GenInfo Identifier: | 11132196 |
| NCBI Gene ID: | 9965 |
| NCBI Accession: | O95750.1 |
| UniProt Related Accession: | O95750 |
| Molecular Weight: | 216 |
| NCBI Full Name: | Fibroblast growth factor 19 |
| NCBI Synonym Full Names: | fibroblast growth factor 19 |
| NCBI Official Symbol: | FGF19 |
| NCBI Protein Information: | fibroblast growth factor 19; FGF-19 |
| UniProt Protein Name: | Fibroblast growth factor 19 |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF19 |
| UniProt Entry Name: | FGF19_HUMAN |
 | Western blot analysis of extracts of SW620 cells, using FGF19 antibody (CAB6589) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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