Antibody Name:	Anti-FGF17 Antibody
Antibody SKU:	CAB17864
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 23-180 of human FGF17 (NP_003858.1).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:1000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	SH-SY5Y, mouse testis, mouse brain, rat testis, rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 23-180 of human FGF17 (NP_003858.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:	IgG
Sequence:	TQGE NHPS PNFN QYVR DQGA MTDQ LSRR QIRE YQLY SRTS GKHV QVTG RRIS ATAE DGNK FAKL IVET DTFG SRVR IKGA ESEK YICM NKRG KLIG KPSG KSKD CVFT EIVL ENNY TAFQ NARH EGWF MAFT RQGR PRQA SRSR QNQR EAHF IKRL YQ
Gene ID:	8822
Uniprot:	O60258
Cellular Location:	Secreted
Calculated MW:	23kDa/24kDa
Observed MW:	24kDa

Synonyms:

FGF17, FGF-13, FGF-17, HH20

Background:

This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants.

UniProt Protein Function:	FGF17: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 8p21 Cellular Component: extracellular region; extracellular space Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; nervous system development; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; signal transduction Disease: Hypogonadotropic Hypogonadism 20 With Or Without Anosmia
NCBI Summary:	This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
UniProt Code:	O60258
NCBI GenInfo Identifier:	6015147
NCBI Gene ID:	8822
NCBI Accession:	O60258.1
UniProt Secondary Accession:	O60258,Q2M2W1, B7ZLG4,
UniProt Related Accession:	O60258
Molecular Weight:	23,669 Da
NCBI Full Name:	Fibroblast growth factor 17
NCBI Synonym Full Names:	fibroblast growth factor 17
NCBI Official Symbol:	FGF17
NCBI Official Synonym Symbols:	HH20; FGF-13; FGF-17
NCBI Protein Information:	fibroblast growth factor 17
UniProt Protein Name:	Fibroblast growth factor 17
Protein Family:	Fibroblast growth factor
UniProt Gene Name:	FGF17
UniProt Entry Name:	FGF17_HUMAN

	Western blot analysis of extracts of various cell lines, using FGF17 antibody (CAB17864) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
	Immunofluorescence analysis of mouse brain using FGF17 antibody (CAB17864) at dilution of 1:100. Blue: DAPI for nuclear staining.