Antibody Name:	Anti-FGF14 Antibody
Antibody SKU:	CAB6588
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human FGF14 (NP_787125.1).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	U-937, Mouse brain, Mouse spleen, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human FGF14 (NP_787125.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MVKP VPLF RRTD FKLL LCNH KDLF FLRV SKLL DCFS PKSM WFLW NIFS KGTH MLQC LCGK SLKK NKNP TDPQ LKGI VTRL YCRQ GYYL QMHP DGAL DGTK DDST NSTL FNLI PVGL RVVA IQGV KTGL YIAM NGEG YLYP SELF TPEC KFKE SVFE NYYV IYSS MLYR QQES GRAW FLGL NKEG QAMK GNRV KKTK PAAH FLPK PLEV AMYR EPSL HDVG ETVP KPGV TPSK STSA SAIM NGGK PVNK SKTT
Gene ID:	2259
Uniprot:	Q92915
Cellular Location:	Nucleus
Calculated MW:	27kDa/28kDa
Observed MW:	28kDa

Synonyms:

FGF14, FGF-14, FHF-4, FHF4, SCA27

Background:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.

UniProt Protein Function:	FGF14: Probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Cytokine; Cell development/differentiation Chromosomal Location of Human Ortholog: 13q34 Cellular Component: extracellular region; nucleus Molecular Function:heparin binding; growth factor activity; fibroblast growth factor receptor binding Biological Process: nervous system development; synaptic transmission; fibroblast growth factor receptor signaling pathway; cell-cell signaling; adult locomotory behavior; neuromuscular process; JNK cascade; signal transduction Disease: Spinocerebellar Ataxia 27
NCBI Summary:	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q92915
NCBI GenInfo Identifier:	2494463
NCBI Gene ID:	2259
NCBI Accession:	Q92915.1
UniProt Secondary Accession:	Q92915,Q86YN7, Q96QX6,
UniProt Related Accession:	Q92915
Molecular Weight:	247
NCBI Full Name:	Fibroblast growth factor 14
NCBI Synonym Full Names:	fibroblast growth factor 14
NCBI Official Symbol:	FGF14
NCBI Official Synonym Symbols:	FHF4; FHF-4; SCA27; FGF-14
NCBI Protein Information:	fibroblast growth factor 14; bA397O8.2; fibroblast growth factor homologous factor 4
UniProt Protein Name:	Fibroblast growth factor 14
UniProt Synonym Protein Names:	Fibroblast growth factor homologous factor 4; FHF-4
Protein Family:	Fibroblast growth factor
UniProt Gene Name:	FGF14
UniProt Entry Name:	FGF14_HUMAN

	Western blot analysis of extracts of various cell lines, using FGF14 antibody (CAB6588) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunofluorescence analysis of U2OS cells using FGF14 antibody (CAB6588).