Cell Biology Antibodies 18

Anti-FFAR4 Antibody (CAB18342)

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SKU:
CAB18342
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FFAR4 Antibody
Antibody SKU:CAB18342
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human FFAR4.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SW480, BxPC-3, A-549, Mouse small intestine, Mouse lung, Rat lung
Immunogen:Recombinant protein of human FFAR4.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:338557
Uniprot:Q5NUL3
Cellular Location:
Calculated MW:42kDa
Observed MW:42kDa
Anti-FFAR4 Antibody (CAB18342)Western blot - FFAR4 Rabbit pAb (CAB18342)
Synonyms:GT01, PGR4, BMIQ10, GPR120, GPR129, O3FAR1, FFAR4
Background:This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:GPR120: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid-binding; Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:fatty acid binding; peptide binding; taste receptor activity

Biological Process: cellular response to hormone stimulus; hormone secretion; negative regulation of apoptosis; negative regulation of cytokine secretion; negative regulation of inflammatory response

Disease: Body Mass Index Quantitative Trait Locus 10

NCBI Summary:This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:Q5NUL3
NCBI GenInfo Identifier:82581671
NCBI Gene ID:338557
NCBI Accession:Q5NUL3.2
UniProt Secondary Accession:Q5NUL3,Q495H1, Q5VY25, Q5VY26, Q7Z605, Q86SM7,
UniProt Related Accession:Q5NUL3
Molecular Weight:40,494 Da
NCBI Full Name:Free fatty acid receptor 4
NCBI Synonym Full Names:free fatty acid receptor 4
NCBI Official Symbol:FFAR4  
NCBI Official Synonym Symbols:GT01; PGR4; BMIQ10; GPR120; GPR129; O3FAR1  
NCBI Protein Information:free fatty acid receptor 4
UniProt Protein Name:Free fatty acid receptor 4
UniProt Synonym Protein Names:G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; Omega-3 fatty acid receptor 1
Protein Family:Free fatty acid receptor
UniProt Gene Name:FFAR4  
UniProt Entry Name:FFAR4_HUMAN
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