Immunology Antibodies 1
Anti-FFAR3 Antibody (CAB12636)
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- SKU:
- CAB12636
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-FFAR3 Antibody |
| Antibody SKU: | CAB12636 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 257-346 of human FFAR3 (NP_005295.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 257-346 of human FFAR3 (NP_005295.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WRIY VTLL STLN SCVD PFVY YFSS SGFQ ADFH ELLR RLCG LWGQ WQQE SSME LKEQ KGGE EQRA DRPA ERKT SEHS QGCG TGGQ VACA ES |
| Gene ID: | 2865 |
| Uniprot: | O14843 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 38kDa |
| Observed MW: | 43kDa |
| Synonyms: | FFAR3, FFA3R, GPR41, GPR42 |
| Background: |
| UniProt Protein Function: | FFAR3: Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5- trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; mucosal immune response; negative regulation of blood pressure; positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of chemokine production; positive regulation of cytokine production during immune response; regulation of hormone biosynthetic process; regulation of norepinephrine secretion |
| UniProt Code: | O14843 |
| NCBI GenInfo Identifier: | 3122158 |
| NCBI Gene ID: | 2865 |
| NCBI Accession: | O14843.1 |
| UniProt Secondary Accession: | O14843,Q14CM7, B2RWM8, |
| UniProt Related Accession: | O14843 |
| Molecular Weight: | 39kDa |
| NCBI Full Name: | Free fatty acid receptor 3 |
| NCBI Synonym Full Names: | free fatty acid receptor 3 |
| NCBI Official Symbol: | FFAR3 |
| NCBI Official Synonym Symbols: | FFA3R; GPR41; GPR42 |
| NCBI Protein Information: | free fatty acid receptor 3 |
| UniProt Protein Name: | Free fatty acid receptor 3 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 41 |
| Protein Family: | Free fatty acid receptor |
| UniProt Gene Name: | FFAR3 |
 | Western blot analysis of extracts of various cell lines, using FFAR3 antibody (CAB12636) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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