Cell Biology Antibodies 7
Anti-FFAR1 Antibody (CAB16379)
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- SKU:
- CAB16379
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FFAR1 Antibody |
| Antibody SKU: | CAB16379 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human FFAR1 (NP_005294.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, BxPC-3 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human FFAR1 (NP_005294.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FCYV GCLR ALAR SGLT HRRK LRAA WVAG GALL TLLL CVGP YNAS NVAS FLYP NLGG SWRK LGLI TGAW SVVL NPLV TGYL GRGP GLKT VCAA RTQG GKSQ K |
| Gene ID: | 2864 |
| Uniprot: | O14842 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 31kDa |
| Observed MW: | 36kDa |
| Synonyms: | FFAR1, FFA1R, GPCR40, GPR40 |
| Background: | This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. |
| UniProt Protein Function: | FFAR1: Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:bioactive lipid receptor activity; G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; lipid binding Biological Process: energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; glucose homeostasis; insulin secretion; positive regulation of calcium ion transport; positive regulation of GTPase activity; positive regulation of insulin secretion; regulation of insulin secretion |
| NCBI Summary: | This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009] |
| UniProt Code: | O14842 |
| NCBI GenInfo Identifier: | 3122157 |
| NCBI Gene ID: | 2864 |
| NCBI Accession: | O14842.1 |
| UniProt Secondary Accession: | O14842,Q0VAS2, Q4VBL4, |
| UniProt Related Accession: | O14842 |
| Molecular Weight: | |
| NCBI Full Name: | Free fatty acid receptor 1 |
| NCBI Synonym Full Names: | free fatty acid receptor 1 |
| NCBI Official Symbol: | FFAR1 |
| NCBI Official Synonym Symbols: | FFA1R; GPR40; GPCR40 |
| NCBI Protein Information: | free fatty acid receptor 1 |
| UniProt Protein Name: | Free fatty acid receptor 1 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 40 |
| Protein Family: | Free fatty acid receptor |
| UniProt Gene Name: | FFAR1 |
| UniProt Entry Name: | FFAR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FFAR1 antibody (CAB16379) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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