Developmental Biology

Anti-FEV Antibody (CAB17377)

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SKU:
CAB17377
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-FEV Antibody
Antibody SKU:CAB17377
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human FEV.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide of human FEV.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:54738
Uniprot:Q99581
Cellular Location:
Calculated MW:25kDa
Observed MW:Refer to figures
Synonyms:FEV, HSRNAFEV, PET-1
Background:This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations.
UniProt Protein Function:FEV: Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. Genetic variation in FEV may be associated with susceptibility to sudden infant death syndrome (SIDS). SIDS remains elusive in its causes and devastating in its consequences. Despite the impressive decline in the incidence of SIDS since the recommendation to avoid the prone sleep position, SIDS remains a leading cause of death in the first year of life. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. Belongs to the ETS family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 2q36

Cellular Component: nucleus

Molecular Function:transcription corepressor activity; transcription factor activity

Biological Process: cell differentiation; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

NCBI Summary:This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
UniProt Code:Q99581
NCBI GenInfo Identifier:74762701
NCBI Gene ID:54738
NCBI Accession:Q99581.1
UniProt Related Accession:Q99581
Molecular Weight:25,030 Da
NCBI Full Name:Protein FEV
NCBI Synonym Full Names:FEV, ETS transcription factor
NCBI Official Symbol:FEV  
NCBI Official Synonym Symbols:PET-1; HSRNAFEV  
NCBI Protein Information:protein FEV
UniProt Protein Name:Protein FEV
UniProt Synonym Protein Names:Fifth Ewing variant protein; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1
Protein Family:Protein
UniProt Gene Name:FEV  
UniProt Entry Name:FEV_HUMAN
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