Cell Biology Antibodies 8

Anti-FES Antibody (CAB2578)

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SKU:
CAB2578
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FES Antibody
Antibody SKU:CAB2578
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-420 of human FES (NP_001137256.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse heart, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-420 of human FES (NP_001137256.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WQQL QQEL TKTH SQDI EKLK SQYR ALAR DSAQ AKRK YQEA SKDK DRDK AKDK YVRS LWKL FAHH NRYV LGVR AAQL HHQH HHQL LLPG LLRS LQDL HEEM ACIL KEIL QEYL EISS LVQD EVVA IHRE MAAA AARI QPEA EYQG FLRQ YGSA PDVP PCVT FDES LLEE GEPL EPGE LQLN ELTV ESVQ HTLT SVTD ELAV ATEM VFRR QEMV TQLQ QELR NEEE NTHP RERV QLLG KRQV LQEA LQGL QVAL CSQA KLQA QQEL LQTK LEHL GPGE PPPV LLLQ DDRH STSS SEQE REGG R
Gene ID:2242
Uniprot:P07332
Cellular Location:Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus, Peripheral membrane protein, cytoskeleton, cytosol, focal adhesion
Calculated MW:78kDa/85kDa/86kDa/93kDa
Observed MW:98kDa
Synonyms:FES, FPS
Background:This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.
UniProt Protein Function:Fes: a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene.
UniProt Protein Details:

Protein type:EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Oncoprotein; Tumor suppressor; TK group; Fer family

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: microtubule cytoskeleton; Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasmic membrane-bound vesicle; cytoplasm; cytoplasmic vesicle; cytosol

Molecular Function:protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; ATP binding

Biological Process: regulation of mast cell degranulation; epidermal growth factor receptor signaling pathway; regulation of cell adhesion; axon guidance; cell migration; peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; protein amino acid autophosphorylation; multicellular organismal development; positive regulation of microtubule polymerization; chemotaxis; protein amino acid phosphorylation; regulation of cell proliferation; cell proliferation; regulation of cell shape; regulation of cell differentiation; innate immune response

NCBI Summary:This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
UniProt Code:P07332
NCBI GenInfo Identifier:115502390
NCBI Gene ID:2242
NCBI Accession:P07332.3
UniProt Secondary Accession:P07332,Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5, B2R6E6, B4DUD0 E9PC94, E9PC95,
UniProt Related Accession:P07332
Molecular Weight:85,466 Da
NCBI Full Name:Tyrosine-protein kinase Fes/Fps
NCBI Synonym Full Names:FES proto-oncogene, tyrosine kinase
NCBI Official Symbol:FES  
NCBI Official Synonym Symbols:FPS  
NCBI Protein Information:tyrosine-protein kinase Fes/Fps; p93c-fes; proto-oncogene c-Fes; proto-oncogene c-Fps; feline sarcoma oncogene; Oncogene FES, feline sarcoma virus; proto-oncogene tyrosine-protein kinase Fes/Fps; feline sarcoma/Fujinami avian sarcoma oncogene homolog; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
UniProt Protein Name:Tyrosine-protein kinase Fes/Fps
UniProt Synonym Protein Names:Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes
Protein Family:Festuclavine dehydrogenase
UniProt Gene Name:FES  
UniProt Entry Name:FES_HUMAN
Anti-FES Antibody (CAB2578)Western blot analysis of extracts of various cell lines, using FES antibody (CAB2578) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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