Cell Biology Antibodies 2
Anti-Ferritin Heavy Chain Antibody (CAB1144)
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- SKU:
- CAB1144
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Ferritin Heavy Chain Antibody |
| Antibody SKU: | CAB1144 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human Ferritin Heavy Chain (NP_002023.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human Ferritin Heavy Chain (NP_002023.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTTA STSQ VRQN YHQD SEAA INRQ INLE LYAS YVYL SMSY YFDR DDVA LKNF AKYF LHQS HEER EHAE KLMK LQNQ RGGR IFLQ DIKK PDCD DWES GLNA MECA LHLE KNVN QSLL ELHK LATD KNDP HLCD FIET HYLN EQVK AIKE LGDH VTNL RKMG APES GLAE YLFD KHTL GDSD NES |
| Gene ID: | 2495 |
| Uniprot: | P02794 |
| Cellular Location: | |
| Calculated MW: | 21kDa |
| Observed MW: | 21KDa |
| Synonyms: | FHC, FTH, FTHL6, HFE5, PIG15, PLIF, Ferritin, FTH1 |
| Background: | This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. |
| UniProt Protein Function: | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. |
| NCBI Summary: | This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02794 |
| NCBI GenInfo Identifier: | 120516 |
| NCBI Gene ID: | 2495 |
| NCBI Accession: | P02794.2 |
| UniProt Secondary Accession: | P02794,Q3KRA8, Q3SWW1, B3KNR5, |
| UniProt Related Accession: | P02794 |
| Molecular Weight: | |
| NCBI Full Name: | Ferritin heavy chain |
| NCBI Synonym Full Names: | ferritin, heavy polypeptide 1 |
| NCBI Official Symbol: | FTH1 |
| NCBI Official Synonym Symbols: | FHC; FTH; HFE5; PLIF; FTHL6; PIG15 |
| NCBI Protein Information: | ferritin heavy chain |
| UniProt Protein Name: | Ferritin heavy chain |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 15 protein |
| Protein Family: | Iron transporter |
| UniProt Gene Name: | FTH1 |
| UniProt Entry Name: | FRIH_HUMAN |
 | Western blot analysis of extracts of Mouse heart, using Ferritin Heavy Chain antibody (CAB1144) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded rat liver using Ferritin Heavy Chain Rabbit pAb (CAB1144) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human thyroid cancer using Ferritin Heavy Chain Rabbit pAb (CAB1144) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using Ferritin Heavy Chain Rabbit pAb (CAB1144) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using Ferritin Heavy Chain Rabbit pAb (CAB1144) at dilution of 1:100 (40x lens). |
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