Cell Biology Antibodies 12

Anti-FERMT2 Antibody (CAB8709)

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SKU:
CAB8709
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FERMT2 Antibody
Antibody SKU:CAB8709
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 380-550 of human FERMT2 (NP_006823.1).
Application:WB IHC
Recommended Dilution:WB 1:1000 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, HT-29, LO2, MCF7, HT-1080, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 380-550 of human FERMT2 (NP_006823.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KVFK PKKL TLKG YKQY WCTF KDTS ISCY KSKE ESSG TPAH QMNL RGCE VTPD VNIS GQKF NIKL LIPV AEGM NEIW LRCD NEKQ YAHW MAAC RLAS KGKT MADS SYNL EVQN ILSF LKMQ HLNP DPQL IPEQ ITTD ITPE CLVS PRYL KKYK NKQI TARI LEAH QNVA QMS
Gene ID:10979
Uniprot:Q96AC1
Cellular Location:Cell junction, Cell projection, Cell surface, Cytoplasm, Cytoplasmic side, I band, Membrane, Nucleus, Peripheral membrane protein, cell cortex, cytoskeleton, focal adhesion, lamellipodium membrane, myofibril, sarcomere
Calculated MW:72kDa/77kDa/78kDa
Observed MW:78kDa
Synonyms:FERMT2, KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2
Background:
UniProt Protein Function:kindlin-2: Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites. Belongs to the kindlin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; nucleoplasm; nucleus

Molecular Function:phosphatidylinositol-3,4,5-triphosphate binding; protein binding

Biological Process: cell-matrix adhesion; focal adhesion formation; integrin activation; integrin-mediated signaling pathway; transforming growth factor beta receptor signaling pathway; Wnt receptor signaling pathway

UniProt Code:Q96AC1
NCBI GenInfo Identifier:38258220
NCBI Gene ID:10979
NCBI Accession:Q96AC1.1
UniProt Secondary Accession:Q96AC1,Q14840, Q86TY7, B5TJY2,
UniProt Related Accession:Q96AC1
Molecular Weight:78,675 Da
NCBI Full Name:Fermitin family homolog 2
NCBI Synonym Full Names:fermitin family member 2
NCBI Official Symbol:FERMT2  
NCBI Official Synonym Symbols:MIG2; KIND2; mig-2; UNC112; PLEKHC1; UNC112B  
NCBI Protein Information:fermitin family homolog 2
UniProt Protein Name:Fermitin family homolog 2
UniProt Synonym Protein Names:Kindlin-2; Mitogen-inducible gene 2 protein; MIG-2; Pleckstrin homology domain-containing family C member 1; PH domain-containing family C member 1
Protein Family:Fermitin family
UniProt Gene Name:FERMT2  
UniProt Entry Name:FERM2_HUMAN
Anti-FERMT2 Polyclonal Antibody (CAB8709)Western blot analysis of extracts of various cell lines, using FERMT2 antibody (CAB8709) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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