Cell Death Antibodies 1

Anti-FEM1B Antibody (CAB12803)

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SKU:
CAB12803
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-FEM1B Antibody
Antibody SKU:CAB12803
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 368-627 of human FEM1B (NP_056137.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 368-627 of human FEM1B (NP_056137.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LHAL HLRQ KGNR NTHK DLLR FAQV FSQM IHLN ETVK APDI ECVL RCSV LEIE QSMN RVKN ISDA DVHN AMDN YECN LYTF LYLV CIST KTQC SEED QCKI NKQI YNLI HLDP RTRE GFTL LHLA VNSN TPVD DFHT NDVC SFPN ALVT KLLL DCGA EVNA VDNE GNSA LHII VQYN RPIS DFLT LHSI IISL VEAG AHTD MTNK QNKT PLDK STTG VSEI LLKT QMKM SLKC LAAR AVRA NDIN YQDQ IPRT LEEF VGFH
Gene ID:10116
Uniprot:Q9UK73
Cellular Location:Cytoplasm, Nucleus
Calculated MW:70kDa
Observed MW:Refer to Figures
Synonyms:FEM1B, F1A-ALPHA, F1AA, FEM1-beta
Background:This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1.
UniProt Protein Function:FEM1B: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. Belongs to the fem-1 family.
UniProt Protein Details:

Protein type:Apoptosis; Cell development/differentiation; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function:death receptor binding; protein binding; ubiquitin-protein ligase activity

Biological Process: regulation of ubiquitin-protein ligase activity

NCBI Summary:This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
UniProt Code:Q9UK73
NCBI GenInfo Identifier:74753369
NCBI Gene ID:10116
NCBI Accession:Q9UK73.1
UniProt Secondary Accession:Q9UK73,O43146,
UniProt Related Accession:Q9UK73
Molecular Weight:70kDa
NCBI Full Name:Protein fem-1 homolog B
NCBI Synonym Full Names:fem-1 homolog B
NCBI Official Symbol:FEM1B  
NCBI Official Synonym Symbols:F1AA; F1A-ALPHA; FEM1-beta  
NCBI Protein Information:protein fem-1 homolog B
UniProt Protein Name:Protein fem-1 homolog B
UniProt Synonym Protein Names:FEM1-beta; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; F1A-alpha
UniProt Gene Name:FEM1B  
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