Immunology Antibodies 1

Anti-FCRL4 Antibody (CAB10329)

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SKU:
CAB10329
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-FCRL4 Antibody
Antibody SKU:CAB10329
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-387 of human FCRL4 (NP_112572.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, B cells, 293T, Mouse kidney, Mouse liver, Rat kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-387 of human FCRL4 (NP_112572.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VLRC HRRR KEKL TAVK YTWN GNIL SISN KSWD LLIP QASS NNNG NYRC IGYG DEND VFRS NFKI IKIQ ELFP HPEL KATD SQPT EGNS VNLS CETQ LPPE RSDT PLHF NFFR DGEV ILSD WSTY PELQ LPTV WREN SGSY WCGA ETVR GNIH KHSP SLQI HVQR IPVS GVLL ETQP SGGQ AVEG EMLV LVCS VAEG TGDT TFSW HRED MQES LGRK TQRS LRAE LELP AIRQ SHAG GYYC TADN SYGP VQSM VLNV TVRE TPGN RDGL
Gene ID:83417
Uniprot:Q96PJ5
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:56kDa/57kDa
Observed MW:57kDa
Synonyms:FCRL4, CD307d, FCRH4, IGFP2, IRTA1
Background:This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma.
UniProt Protein Function:FCRL4: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Molecular Function:protein binding

NCBI Summary:This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
UniProt Code:Q96PJ5
NCBI GenInfo Identifier:74761029
NCBI Gene ID:83417
NCBI Accession:Q96PJ5.1
UniProt Secondary Accession:Q96PJ5,Q96PJ3, Q96RE0,
UniProt Related Accession:Q96PJ5
Molecular Weight:57kDa
NCBI Full Name:Fc receptor-like protein 4
NCBI Synonym Full Names:Fc receptor like 4
NCBI Official Symbol:FCRL4  
NCBI Official Synonym Symbols:FCRH4; IGFP2; IRTA1; CD307d  
NCBI Protein Information:Fc receptor-like protein 4
UniProt Protein Name:Fc receptor-like protein 4
UniProt Synonym Protein Names:Fc receptor homolog 4; FcRH4; IFGP family protein 2; hIFGP2; Immune receptor translocation-associated protein 1; CD_antigen: CD307d
Protein Family:Fc receptor-like protein
UniProt Gene Name:FCRL4  
Anti-FCRL4 Antibody (CAB10329)Western blot analysis of extracts of various cell lines, using FCRL4 antibody (CAB10329) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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