Cell Biology Antibodies 1

Anti-FCRL2 Antibody (CAB10324)

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SKU:
CAB10324
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FCRL2 Antibody
Antibody SKU:CAB10324
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human FCRL2
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:Raji
Immunogen:Recombinant protein of human FCRL2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:79368
Uniprot:Q96LA5
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:15kDa/20kDa/22kDa/27kDa/55kDa
Observed MW:45kDa
Synonyms:FCRL2, CD307b, FCRH2, IFGP4, IRTA4, SPAP1, SPAP1A, SPAP1B, SPAP1C
Background:This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
UniProt Protein Function:FCRL2: May have an regulatory role in normal and neoplastic B cell development. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Molecular Function:protein binding; SH3/SH2 adaptor activity

NCBI Summary:This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]
UniProt Code:Q96LA5
NCBI GenInfo Identifier:68052374
NCBI Gene ID:79368
NCBI Accession:Q96LA5.1
UniProt Secondary Accession:Q96LA5,Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6, A0N0M5, A1L307 A6NMS0,
UniProt Related Accession:Q96LA5
Molecular Weight:56kDa
NCBI Full Name:Fc receptor-like protein 2
NCBI Synonym Full Names:Fc receptor like 2
NCBI Official Symbol:FCRL2  
NCBI Official Synonym Symbols:FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C  
NCBI Protein Information:Fc receptor-like protein 2
UniProt Protein Name:Fc receptor-like protein 2
UniProt Synonym Protein Names:Fc receptor homolog 2; FcRH2; IFGP family protein 4; Immunoglobulin receptor translocation-associated protein 4; SH2 domain-containing phosphatase anchor protein 1; CD_antigen: CD307b
Protein Family:Fc receptor-like protein
UniProt Gene Name:FCRL2  
Anti-FCRL2 Antibody (CAB10324)Western blot analysis of extracts of Raji cells, using FCRL2 antibody (CAB10324) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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