Immunology Antibodies 2

Anti-FCN3 Antibody (CAB17352)

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SKU:
CAB17352
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-FCN3 Antibody
Antibody SKU:CAB17352
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 13-288 of human FCN3 (NP_775628.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:A-549, mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 13-288 of human FCN3 (NP_775628.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLLG GPAC LKTQ EHPS CPGP RELE ASKV VLLP SCPG APGS PGEK GAPG PQGP PGPP GKMG PKGE PGPR NCRE LLSQ GATL SGWY HLCL PEGR ALPV FCDM DTEG GGWL VFQR RQDG SVDF FRSW SSYR AGFG NQES EFWL GNEN LHQL TLQG NWEL RVEL EDFN GNRT FAHY ATFR LLGE VDHY QLAL GKFS EGTA GDSL SLHS GRPF TTYD ADHD SSNS NCAV IVHG AWWY ASCY RSNL NGRY AVSE AAAH KYGI DWAS GRGV GHPY RRVR MMLR
Gene ID:8547
Uniprot:O75636
Cellular Location:Secreted
Calculated MW:31kDa/32kDa
Observed MW:38kDa
Synonyms:FCN3, FCNH, HAKA1, ficolin-3
Background:Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
UniProt Protein Function:FCN3: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D). FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: collagen; extracellular region

Molecular Function:protein binding; carbohydrate binding; antigen binding

Biological Process: negative regulation of virion penetration into host cell; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; defense response to virus; complement activation

Disease: Immunodeficiency Due To Ficolin 3 Deficiency

NCBI Summary:Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:O75636
NCBI GenInfo Identifier:90111858
NCBI Gene ID:8547
NCBI Accession:O75636.2
UniProt Secondary Accession:O75636,Q6IBJ5, Q8WW86,
UniProt Related Accession:O75636
Molecular Weight:31,678 Da
NCBI Full Name:Ficolin-3
NCBI Synonym Full Names:ficolin (collagen/fibrinogen domain containing) 3
NCBI Official Symbol:FCN3  
NCBI Official Synonym Symbols:FCNH; HAKA1  
NCBI Protein Information:ficolin-3; H-ficolin; ficolin 3; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
UniProt Protein Name:Ficolin-3
UniProt Synonym Protein Names:Collagen/fibrinogen domain-containing lectin 3 p35; Collagen/fibrinogen domain-containing protein 3; Hakata antigen
Protein Family:Ficolin
UniProt Gene Name:FCN3  
UniProt Entry Name:FCN3_HUMAN
Anti-FCN3 Antibody (CAB17352)Western blot analysis of extracts of various cell lines, using FCN3 antibody (CAB17352) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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