Immunology Antibodies 2
Anti-FCN2 Antibody (CAB16690)
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- SKU:
- CAB16690
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-FCN2 Antibody |
| Antibody SKU: | CAB16690 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-290 of human FCN2 (NP_004099.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | mosue spleen, mouse lung, rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-290 of human FCN2 (NP_004099.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SAGD SLTF HNNQ SFST KDQD NDLN TGNC AVMF QGAW WYKN CHVS NLNG RYLR GTHG SFAN G |
| Gene ID: | 2220 |
| Uniprot: | Q15485 |
| Cellular Location: | |
| Calculated MW: | 34kDa |
| Observed MW: | 34kDa |
| Synonyms: | FCN2, EBP-37, FCNL, P35, ficolin-2 |
| Background: | The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | FCN2: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 9q34 |
| NCBI Summary: | The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15485 |
| NCBI GenInfo Identifier: | 166214934 |
| NCBI Gene ID: | 2220 |
| NCBI Accession: | Q15485.2 |
| UniProt Secondary Accession: | Q15485,Q6IS69, Q7M4P4, Q9UC57, A6NFG7, A8K478, |
| UniProt Related Accession: | Q15485 |
| Molecular Weight: | 30,228 Da |
| NCBI Full Name: | Ficolin-2 |
| NCBI Synonym Full Names: | ficolin (collagen/fibrinogen domain containing lectin) 2 |
| NCBI Official Symbol: | FCN2 |
| NCBI Official Synonym Symbols: | P35; FCNL; EBP-37; ficolin-2 |
| NCBI Protein Information: | ficolin-2; L-ficolin; ficolin B; ficolin-B; ficolin-beta; serum lectin p35; 37 kDa elastin-binding protein; collagen/fibrinogen domain-containing protein 2; ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) |
| UniProt Protein Name: | Ficolin-2 |
| UniProt Synonym Protein Names: | 37 kDa elastin-binding protein; Collagen/fibrinogen domain-containing protein 2; EBP-37; Ficolin-B; Ficolin-beta; Hucolin; L-ficolin; Serum lectin p35 |
| Protein Family: | Ficolin |
| UniProt Gene Name: | FCN2 |
| UniProt Entry Name: | FCN2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FCN2 antibody (CAB16690) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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