Cell Biology Antibodies 8

Anti-FCGR3A Antibody (CAB2552)

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SKU:
CAB2552
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-FCGR3A Antibody
Antibody SKU:CAB2552
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FCGR3A (NP_001121067.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, Mouse liver, Rat liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FCGR3A (NP_001121067.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YFHH NSDF YIPK ATLK DSGS YFCR GLFG SKNV SSET VNIT ITQG LAVS TISS FFPP GYQV SFCL VMVL LFAV DTGL YFSV KTNI RSST RDWK DHKF KWRK D
Gene ID:2214
Uniprot:P08637
Cellular Location:Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:29kDa
Observed MW:50kDa
Synonyms:CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20, FCGR3A
Background:This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:FCGR3A: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function:IgG binding

Biological Process: regulation of immune response; innate immune response; immune response

Disease: Immunodeficiency 20

NCBI Summary:This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P08637
NCBI GenInfo Identifier:119876
NCBI Gene ID:2214
NCBI Accession:P08637.2
UniProt Secondary Accession:P08637,Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0, A2N6W9
UniProt Related Accession:P08637
Molecular Weight:254
NCBI Full Name:Low affinity immunoglobulin gamma Fc region receptor III-A
NCBI Synonym Full Names:Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
NCBI Official Symbol:FCGR3A  
NCBI Official Synonym Symbols:CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA  
NCBI Protein Information:low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-
UniProt Protein Name:Low affinity immunoglobulin gamma Fc region receptor III-A
UniProt Synonym Protein Names:CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a
Protein Family:CD160 antigen
UniProt Gene Name:FCGR3A  
UniProt Entry Name:FCG3A_HUMAN
Anti-FCGR3A Antibody (CAB2552)Western blot analysis of extracts of various cell lines, using FCGR3A antibody (CAB2552) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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