Immunology Antibodies 1
Anti-FCGR2A Antibody (CAB1388)
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- SKU:
- CAB1388
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-FCGR2A Antibody |
| Antibody SKU: | CAB1388 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-316 of human FCGR2A (NP_067674.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | K-562, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-316 of human FCGR2A (NP_067674.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QAAP PKAV LKLE PPWI NVLQ EDSV TLTC QGAR SPES DSIQ WFHN GNLI PTHT QPSY RFKA NNND SGEY TCQT GQTS LSDP VHLT VLSE WLVL QTPH LEFQ EGET IMLR CHSW KDKP LVKV TFFQ NGKS QKFS HLDP TFSI PQAN HSHS GDYH CTGN IGYT LFSS KPVT ITVQ VPSM GSSS PMGI IVAV VIAT AVAA IVAA VVAL IYCR KKRI SANS TDPV KAAQ FEPP GRQM IAIR KRQL EETN NDYE TADG GYMT LNPR APTD DDKN IYLT LPPN DHVN SNN |
| Gene ID: | 2212 |
| Uniprot: | P12318 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 34kDa/35kDa |
| Observed MW: | 40-50KDa |
| Synonyms: | FCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2 |
| Background: | This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | FCGR2A: low affinity receptor for the Fc region of IgGs. Binding to IgG initiates cellular responses against pathogens and soluble antigens. A type I membrane protein found on monocytes, neutrophils and platelets. SHP-1 associates with this protein to modulate signaling events in myeloid cells. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Cell surface Chromosomal Location of Human Ortholog: 1q23 Cellular Component: plasma membrane Molecular Function:protein binding Disease: Malaria, Susceptibility To; Systemic Lupus Erythematosus |
| NCBI Summary: | This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P12318 |
| NCBI GenInfo Identifier: | 160332371 |
| NCBI Gene ID: | 2212 |
| NCBI Accession: | P12318.4 |
| UniProt Secondary Accession: | P12318,Q8WUN1, Q8WW64, |
| UniProt Related Accession: | P12318 |
| Molecular Weight: | 34,930 Da |
| NCBI Full Name: | Low affinity immunoglobulin gamma Fc region receptor II-a |
| NCBI Synonym Full Names: | Fc fragment of IgG receptor IIa |
| NCBI Official Symbol: | FCGR2A |
| NCBI Official Synonym Symbols: | CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1 |
| NCBI Protein Information: | low affinity immunoglobulin gamma Fc region receptor II-a |
| UniProt Protein Name: | Low affinity immunoglobulin gamma Fc region receptor II-a |
| UniProt Synonym Protein Names: | CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD_antigen: CD32 |
| Protein Family: | Low affinity immunoglobulin gamma Fc region receptor |
| UniProt Gene Name: | FCGR2A |
| UniProt Entry Name: | FCG2A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FCGR2A antibody (CAB1388) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of mouse spleen using FCGR2A Rabbit pAb (CAB1388) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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