Immunology Antibodies 1
Anti-FCGR1A Antibody (CAB1197)
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- SKU:
- CAB1197
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-FCGR1A Antibody |
| Antibody SKU: | CAB1197 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-292 of human FCGR1A (NP_000557.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, U-937, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-292 of human FCGR1A (NP_000557.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SPLL EGNL VTLS CETK LLLQ RPGL QLYF SFYM GSKT LRGR NTSS EYQI LTAR REDS GLYW CEAA TEDG NVLK RSPE LELQ VLGL QLPT PVWF H |
| Gene ID: | 2209 |
| Uniprot: | P12314 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 38kDa/42kDa |
| Observed MW: | 70-80kDa |
| Synonyms: | FCGR1A, CD64, CD64A, FCRI, IGFR1 |
| Background: | This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. |
| UniProt Protein Function: | FCGR1A: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Belongs to the immunoglobulin superfamily. FCGR1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q21.2-q21.3 Cellular Component: early endosome membrane; plasma membrane; integral to membrane Molecular Function:protein binding; IgG binding; receptor signaling protein activity Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; signal transduction; phagocytosis, engulfment |
| NCBI Summary: | This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12314 |
| NCBI GenInfo Identifier: | 50403717 |
| NCBI Gene ID: | 2209 |
| NCBI Accession: | P12314.2 |
| UniProt Related Accession: | P12314 |
| Molecular Weight: | |
| NCBI Full Name: | High affinity immunoglobulin gamma Fc receptor I |
| NCBI Synonym Full Names: | Fc fragment of IgG receptor Ia |
| NCBI Official Symbol: | FCGR1A |
| NCBI Official Synonym Symbols: | CD64; FCRI; CD64A; IGFR1 |
| NCBI Protein Information: | high affinity immunoglobulin gamma Fc receptor I |
| UniProt Protein Name: | High affinity immunoglobulin gamma Fc receptor I |
| UniProt Synonym Protein Names: | Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD_antigen: CD64 |
| UniProt Gene Name: | FCGR1A |
| UniProt Entry Name: | FCGR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FCGR1A antibody (CAB1197) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using FCGR1A Rabbit pAb (CAB1197) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using FCGR1A Rabbit pAb (CAB1197) at dilution of 1:100 (40x lens). |
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