Cell Biology Antibodies 7
Anti-FCER1A Antibody (CAB1751)
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- SKU:
- CAB1751
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FCER1A Antibody |
| Antibody SKU: | CAB1751 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-205 of human FCER1A (NP_001992.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K562, HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-205 of human FCER1A (NP_001992.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VPQK PKVS LNPP WNRI FKGE NVTL TCNG NNFF EVSS TKWF HNGS LSEE TNSS LNIV NAKF EDSG EYKC QHQQ VNES EPVY LEVF SDWL LLQA SAEV VMEG QPLF LRCH GWRN WDVY KVIY YKDG EALK YWYE NHNI SITN ATVE DSGT YYCT GKVW QLDY ESEP LNIT VIKA PREK YWLQ |
| Gene ID: | 2205 |
| Uniprot: | P12319 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 29kDa |
| Observed MW: | 68kDa |
| Synonyms: | FCER1A, FCE1A, FcERI |
| Background: | The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. |
| UniProt Protein Function: | Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. |
| NCBI Summary: | The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P12319 |
| NCBI GenInfo Identifier: | 119865 |
| NCBI Gene ID: | 2205 |
| NCBI Accession: | P12319.1 |
| UniProt Related Accession: | P12319 |
| Molecular Weight: | 30kDa |
| NCBI Full Name: | High affinity immunoglobulin epsilon receptor subunit alpha |
| NCBI Synonym Full Names: | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide |
| NCBI Official Symbol: | FCER1A |
| NCBI Official Synonym Symbols: | FCE1A; FcERI |
| NCBI Protein Information: | high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide |
| UniProt Protein Name: | High affinity immunoglobulin epsilon receptor subunit alpha |
| UniProt Synonym Protein Names: | Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha |
| Protein Family: | High affinity immunoglobulin epsilon receptor |
| UniProt Gene Name: | FCER1A |
| UniProt Entry Name: | FCERA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FCER1A antibody (CAB1751). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
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