Cell Biology Antibodies 12
Anti-FCAR Antibody (CAB8888)
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- SKU:
- CAB8888
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FCAR Antibody |
| Antibody SKU: | CAB8888 |
| Antibody Size: | 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human FCAR |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | A synthetic Peptide of human FCAR |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2204 |
| Uniprot: | P24071 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 19-32kDa |
| Observed MW: | 40kDa |
| Synonyms: | FCAR, CD89, CTB-61M7.2, FcalphaRI |
| Background: | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. |
| NCBI Summary: | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24071 |
| NCBI GenInfo Identifier: | 119860 |
| NCBI Gene ID: | 2204 |
| NCBI Accession: | P24071.1 |
| UniProt Related Accession: | P24071 |
| Molecular Weight: | |
| NCBI Full Name: | Immunoglobulin alpha Fc receptor |
| NCBI Synonym Full Names: | Fc fragment of IgA receptor |
| NCBI Official Symbol: | FCAR |
| NCBI Official Synonym Symbols: | CD89; FcalphaRI; CTB-61M7.2 |
| NCBI Protein Information: | immunoglobulin alpha Fc receptor |
| UniProt Protein Name: | Immunoglobulin alpha Fc receptor |
| UniProt Synonym Protein Names: | CD_antigen: CD89 |
| UniProt Gene Name: | FCAR |
 | Western blot analysis of extracts of 293T cells, using FCAR antibody (CAB8888). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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